Cappelli R, Nicora M, Di Perri T
Institute of Medical Pathology, Unviersity of Siena, Italy.
Drugs Exp Clin Res. 1988;14(4):277-83.
The effectiveness and tolerability of a venotropic drug (RAES) composed of an extract of Ruscus aculeatus (16.5 mg), hesperidin (75 mg) and ascorbic acid (50 mg) were evaluated in 40 patients (30 female, 10 male) aged between 28 and 74 years, suffering from chronic phlebopathy of the lower limbs. The cross-over, double-blind trial involved two periods of treatment of 2 months with the drug (2 capsules, 3 times/day) or with placebo, and an interim period of 15 days for wash-out. An overall tendency for improvement occurred that was more distinct during the periods of treatment with the drug. In fact, symptoms and plethysmographic parameters (in particular MVIV 40 and 60) immediately changed significantly in correspondence with the administration of RAES. The biological and clinical tolerability were excellent.
在40例年龄在28至74岁之间、患有下肢慢性静脉病的患者（30名女性，10名男性）中，评估了一种由刺叶番荔枝提取物（16.5毫克）、橙皮苷（75毫克）和抗坏血酸（50毫克）组成的静脉活性药物（RAES）的有效性和耐受性。这项交叉、双盲试验包括两个为期2个月的治疗期，分别使用该药物（2粒胶囊，每日3次）或安慰剂进行治疗，以及一个为期15天的洗脱期。总体上出现了改善的趋势，在使用药物治疗期间更为明显。事实上，与RAES给药相应，症状和体积描记参数（特别是MVIV 40和60）立即发生了显著变化。生物学和临床耐受性良好。
