School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India.
Chem Commun (Camb). 2019 Jan 15;55(6):731-750. doi: 10.1039/c8cc07107a.
The Cu(i)-catalyzed azide and alkyne 1,3-dipolar cycloaddition (CuAAC), commonly known as the "click reaction", has emerged as a powerful and versatile synthetic tool that finds a broad spectrum of applications in chemistry, biology and materials science. The efficiency, selectivity and versatility of the CuAAC reactions have enabled the preparation of vast arrays of triazole compounds with biological and pharmaceutical applications. In this feature article, we outline the applications and future prospects of click chemistry in the synthesis and development of small molecules that target G-quadruplex nucleic acids and show promising biological activities. Furthermore, this article highlights the template-assisted in situ click chemistry for developing G-quadruplex specific ligands and the use of click chemistry for enhancing drug specificity as well as designing imaging and sensor systems to elucidate the biological functions of G-quadruplex nucleic acids in live cells.
铜催化的叠氮化物和炔烃 1,3-偶极环加成（CuAAC），通常称为“点击反应”，已成为一种强大而通用的合成工具，在化学、生物学和材料科学中得到了广泛的应用。CuAAC 反应的效率、选择性和多功能性使得制备具有生物和药物应用的大量三唑化合物成为可能。在这篇专题文章中，我们概述了点击化学在合成和开发靶向 G-四链体核酸的小分子方面的应用和前景，并展示了其具有前景的生物活性。此外，本文还强调了模板辅助的原位点击化学在开发 G-四链体特异性配体方面的应用，以及点击化学在提高药物特异性以及设计成像和传感器系统以阐明 G-四链体核酸在活细胞中的生物学功能方面的应用。
