School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.
Org Lett. 2021 Apr 16;23(8):3004-3009. doi: 10.1021/acs.orglett.1c00685. Epub 2021 Apr 8.
The assembly of guanosine and boronic acids produces anionic hydrogels (G-B hydrogels) that mimic the topology of the DNA G-quadruplex. We herein demonstrate an unconventional approach of using the G-B hydrogel as a supramolecular template that assembles the irreversible formation of DNA G-quadruplex-selective 1,4-triazole ligands from a pool of alkyne-azide building blocks. These generated ligands could also stabilize and strengthen the gel assembly.
鸟嘌呤和硼酸的组装产生了阴离子水凝胶（G-B 水凝胶），模拟了 DNA G-四链体的拓扑结构。本文展示了一种非传统的方法，即使用 G-B 水凝胶作为超分子模板，从炔基-叠氮砌块库中组装不可逆形成的 DNA G-四链体选择性 1,4-三唑配体。这些生成的配体也可以稳定和增强凝胶组装。
