Barneoud P, Rivet J M, Vitiello S, Le Moal M, Neveu P J
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM Unité 259, Université de Bordeaux II, France.
Immunol Lett. 1988 Jul;18(3):201-4. doi: 10.1016/0165-2478(88)90019-3.
Brain norepinephrine, dopamine and serotonin levels were determined in right and left hemisphere from female C3H/He mice 13 days after their immune system was stimulated by an intraperitoneal injection of bacillus Calmette-Guérin (BCG) (10(7) bacilli/mouse). Increased norepinephrine levels were observed in both hemispheres but significantly only in the right one. No concomitant variations in dopamine or serotonin levels were detected. Furthermore, norepinephrine levels in the right hemisphere appeared to be correlated with the ability of lymphocytes to proliferate after concanavalin A stimulation. The modulation of the immune system by the brain neocortex has been previously shown to be lateralized. Here we show that the information from the immune system towards the central nervous system also appears to be expressed in a lateralized manner.
在雌性C3H/He小鼠经腹腔注射卡介苗（BCG）（10⁷ 菌/小鼠）刺激免疫系统13天后，测定其左右脑半球的去甲肾上腺素、多巴胺和血清素水平。在两个脑半球均观察到去甲肾上腺素水平升高，但仅在右半球显著升高。未检测到多巴胺或血清素水平的相应变化。此外，右半球的去甲肾上腺素水平似乎与刀豆球蛋白A刺激后淋巴细胞的增殖能力相关。先前已表明大脑新皮质对免疫系统的调节具有偏侧化。在此我们表明，从免疫系统到中枢神经系统的信息似乎也以偏侧化方式表达。
