Deleplanque B, Delrue C, Vitiello S, Neveu P J
INSERM U 259-Université de Bordeaux II.
Int J Neurosci. 1993 Dec;73(3-4):287-98. doi: 10.3109/00207459308986677.
Concentrations of brain monoamines from various cerebral structures were determined in right and left sides of the brain from female mice selected for paw preference and injected or not with BCG 8 weeks before. BCG-induced changes in brain monoamine distribution in prefrontal cortex, medial hypothalamus and brain stem were only observed in right-handers. In the posterior hypothalamus, even though there was no BCG effect, norepinephrine asymmetry observed in right-handed controls was suppressed after BCG-injection. Moreover, BCG-induced brain monoamine changes in right-handers mainly involved the right hemisphere except the NE decrease in brain stem which was left-sided. This work demonstrates that the injection of BCG leads to long lasting asymmetrical changes in brain monoamine distribution that furthermore depend on behavioral lateralization of mice.
对根据爪偏好选择的雌性小鼠的左右脑各不同脑区结构中的脑单胺浓度进行了测定，这些小鼠在8周前已注射或未注射卡介苗（BCG）。卡介苗诱导的前额叶皮质、内侧下丘脑和脑干中脑单胺分布的变化仅在右利手小鼠中观察到。在下丘脑后部，尽管没有卡介苗效应，但卡介苗注射后，右利手对照组中观察到的去甲肾上腺素不对称性受到抑制。此外，卡介苗诱导的右利手小鼠脑单胺变化主要涉及右半球，脑干中去甲肾上腺素减少的情况除外，脑干中的去甲肾上腺素减少发生在左侧。这项研究表明，注射卡介苗会导致脑单胺分布出现长期的不对称变化，而且这种变化还取决于小鼠的行为偏侧化。
