Morales Kevin, Samper Katia G, Peña Quim, Hernando Jordi, Lorenzo Julia, Rodríguez-Diéguez Antonio, Capdevila Mercè, Figueredo Marta, Palacios Òscar, Bayón Pau
Departament de Química , Universitat Autònoma de Barcelona , 08193 Cerdanyola del Vallès , Spain.
Aix Marseille Univ, CNRS, Cent Marseille, iSm2 , 13013 Marseille , France.
Inorg Chem. 2018 Dec 17;57(24):15517-15525. doi: 10.1021/acs.inorgchem.8b02854. Epub 2018 Nov 29.
Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.
已合成并全面表征了两种新型基于方酰胺的铂（II）配合物C1和C2。对它们的光响应进行了评估并展开讨论。两种配合物在照射后均观察到DNA结合活性显著增强。对于C2，研究了其照射引发的Pt（II）释放。发现C2的响应受氧气存在的调节。体外细胞毒性测试表明，在缺氧条件下选择性照射后，配合物C2的活性增强。已分离出产生的Pt（II）物种，并通过各种分析方法对其进行了表征，确立了这类基于方酰胺的配合物作为新型Pt（II）光笼概念验证的地位。
