a Department of Molecular Biosciences , Radiation Effects Research Foundation , Minami ku , Hiroshima , Japan.
b Department of Statistics , Radiation Effects Research Foundation , Minami ku , Hiroshima , Japan.
Int J Radiat Biol. 2019 Mar;95(3):321-328. doi: 10.1080/09553002.2019.1552807. Epub 2019 Jan 8.
Cancer risks for Nagasaki survivors once appeared to be lower than for Hiroshima survivors. The possibility that this was due to overestimation of the doses for the Nagasaki survivors was tested by measuring biological doses of Nagasaki survivors and comparing them with DS02R1 individual doses as previously done for Hiroshima survivors.
The electron spin resonance (ESR) method and cytogenetic method were used to estimate radiation doses for 24 Nagasaki survivors, and the results were compared to calculated DS02R1 doses.
Six factory workers and 10 other survivors showed ESR or cytogenetically estimated doses that were in reasonably good agreement with their DS02R1 doses, while one factory worker was found to have an ESR dose estimate of nearly one half of the DS02R1 dose to the eye lens (a proxy organ for teeth). A few outliers were also observed.
Although apparently lower cancer risks were observed in the past for Nagasaki survivors when compared to Hiroshima survivors, the present results do not indicate the existence of a trend that DS02R1 doses are overestimated when compared with biologically estimated tooth or cytogenetic doses. This observation is in line with the recent disappearance of the city difference in cancer risks.
长崎幸存者的癌症风险似乎曾经低于广岛幸存者。为了验证这种情况是由于高估了长崎幸存者的剂量，我们通过测量 24 名长崎幸存者的生物剂量，并将其与之前为广岛幸存者所做的 DS02R1 个体剂量进行比较，对这一可能性进行了测试。
我们使用电子自旋共振（ESR）法和细胞遗传学方法来估计 24 名长崎幸存者的辐射剂量，并将结果与计算得出的 DS02R1 剂量进行比较。
6 名工厂工人和 10 名其他幸存者的 ESR 或细胞遗传学估计剂量与他们的 DS02R1 剂量相当吻合，而一名工厂工人的 ESR 剂量估计值接近 DS02R1 眼部剂量（牙齿的替代器官）的一半。还观察到一些离群值。
尽管过去长崎幸存者的癌症风险明显低于广岛幸存者，但目前的结果并未表明与生物估计的牙齿或细胞遗传学剂量相比，DS02R1 剂量存在被高估的趋势。这一观察结果与最近癌症风险的城市差异消失相一致。
