Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Pancreatology. 2019 Jan;19(1):50-56. doi: 10.1016/j.pan.2018.11.010. Epub 2018 Nov 22.
BACKGROUND/OBJECTIVES: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component.
The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Clinicopathological factors were compared between PNETs with and without a cystic component. Expression of somatostatin 2 receptor (SSTR-2) was also analyzed.
Cystic PNETs were diagnosed in 14 patients (19%). The proportion of men was significantly higher for cystic than solid PNETs (79% vs. 44%, P < 0.05) and cystic PNETs were significantly larger than solid PNETs (25 mm vs. 17 mm, P < 0.01). However, there were no significant differences in the prevalence of lymph node metastases (14% vs. 10%, P = 0.64), hepatic metastasis (7% vs. 3%, P = 0.54), or disease-free survival rate (both 86%, P = 0.29) between PNETs with and without a cystic component. SSTR-2 expression was more frequently observed in PNETs with a cystic component than in those without (100% vs. 70%, P < 0.01).
Although cystic PNETs were larger upon diagnosis than solid PNETs in this study, prognosis after surgical resection did not differ significantly between these types of PNET. Somatostatin receptor scintigraphy and somatostatin analogues may be more useful for diagnosing and treating cystic PNETs, respectively.
背景/目的：囊性胰腺神经内分泌肿瘤（PNET）的生物学特征尚不清楚。本研究旨在阐明具有囊性成分的无功能性 PNET（NF-PNET）的临床病理特征。
回顾性分析了在我院接受手术切除的 75 例 NF-PNET 患者的病历。比较了具有和不具有囊性成分的 PNET 之间的临床病理因素。还分析了生长抑素 2 受体（SSTR-2）的表达。
囊性 PNET 诊断 14 例（19%）。囊性比实体性 PNET 中男性的比例明显更高（79%比 44%，P<0.05），且囊性 PNET 明显大于实体性 PNET（25mm 比 17mm，P<0.01）。然而，具有和不具有囊性成分的 PNET 之间在淋巴结转移的发生率（14%比 10%，P=0.64）、肝转移的发生率（7%比 3%，P=0.54）或无病生存率（均为 86%，P=0.29）方面均无显著差异。具有囊性成分的 PNET 中 SSTR-2 的表达较不具有囊性成分的更频繁（100%比 70%，P<0.01）。
尽管在本研究中，囊性 PNET 在诊断时比实体性 PNET 更大，但手术切除后的预后在这两种类型的 PNET 之间没有显著差异。生长抑素受体闪烁显像和生长抑素类似物可能分别更有助于诊断和治疗囊性 PNET。
