Aromtech Ltd, Tornio, Finland.
Finnsusp Ltd, Lieto, Finland.
Cont Lens Anterior Eye. 2019 Aug;42(4):428-433. doi: 10.1016/j.clae.2018.11.011. Epub 2018 Nov 26.
To investigate the effects of a sea buckthorn oil and sodium hyaluronate-containing eyelid spray emulsion (SB spray) on dry eye.
A randomized controlled study was carried out. Adults (25-70 years) with Ocular Surface Disease Index (OSDI) ≥20 and moderate or severe dryness, burning or grittiness of the eyes were included. In study part one (n = 2), SB spray was used on both closed eyelids four times in one day. In part two (n = 10), SB spray was used on one randomized eyelid, and a commercial reference spray on the other for nine days. In part three (n = 40), eyes were randomized to one eye receiving SB spray and an untreated control for 1.5 months. Dry eye tests were carried out at baseline, during, and at the end of each study section. Symptoms were recorded in questionnaires and daily logs.
In part one, the SB spray was well tolerated. In part two, OSDI decreased significantly (P = 0.022) in the SB spray eye compared to the reference spray, indicating a beneficial effect on symptoms. In part three, OSDI in the SB spray eye decreased significantly compared to the untreated control (P = 0.0007). The scores for dryness at the study end were lower in the SB spray eye compared to control (P = 0.0070). Symptom sums and frequencies of dryness (sum P = 0.0046, frequency P = 0.0016) and watering (sum P = 0.0003, frequency P = 0.013) in the daily logs were lower in the eye treated with SB spray.
SB spray on closed eyelids relieved the symptoms of dry eye.
研究沙棘油和透明质酸钠含眼睑喷雾乳液（SB 喷雾）对干眼症的影响。
进行了一项随机对照研究。纳入患有眼表疾病指数（OSDI）≥20 且眼睛有中度或重度干燥、灼热或磨砂感的成年人（25-70 岁）。在研究部分 1（n=2）中，每天在闭合的眼睑上使用 SB 喷雾四次。在部分 2（n=10）中，SB 喷雾使用于一只随机的眼睑，商业参考喷雾使用于另一只眼睑，持续 9 天。在部分 3（n=40）中，眼睛随机接受 SB 喷雾治疗和未治疗的对照治疗 1.5 个月。在基线、研究期间和每个研究部分结束时进行干眼测试。症状记录在问卷和每日日志中。
在部分 1 中，SB 喷雾耐受性良好。在部分 2 中，与参考喷雾相比，SB 喷雾眼的 OSDI 显著降低（P=0.022），表明对症状有有益的影响。在部分 3 中，与未治疗的对照组相比，SB 喷雾眼的 OSDI 显著降低（P=0.0007）。与对照组相比，SB 喷雾眼在研究结束时的干燥评分较低（P=0.0070）。在每日日志中，与对照组相比，SB 喷雾眼的症状总和和干燥频率（总和 P=0.0046，频率 P=0.013）和流泪频率（总和 P=0.0003，频率 P=0.013）较低。
闭合眼睑上使用 SB 喷雾可缓解干眼症症状。
