Department of Molecular Medicine, University of Padua, Padua, Italy.
Department of Molecular Medicine, University of Padua, Padua, Italy; IFOM, The FIRC Institute of Molecular Oncology, Padua, Italy.
Trends Mol Med. 2019 Jan;25(1):5-7. doi: 10.1016/j.molmed.2018.11.002. Epub 2018 Nov 26.
Reporting in Molecular Cell, Han et al. (2018;2:328-340) show that phosphatidic acid promotes YAP activity through a double-hit inhibition of the LATS kinases, suggesting a therapeutic opportunity for the treatment of YAP/TAZ-dependent cancers and opening new prospects on the connections between lipid signaling and YAP/TAZ biology.
在《Molecular Cell》杂志上，Han 等人（2018 年；2:328-340）表明，磷酸脂酸通过双重抑制 LATS 激酶来促进 YAP 的活性，这为治疗依赖于 YAP/TAZ 的癌症提供了一个治疗机会，并为脂质信号与 YAP/TAZ 生物学之间的联系开辟了新的前景。
