Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
Bioessays. 2017 Oct;39(10). doi: 10.1002/bies.201700116. Epub 2017 Sep 11.
How epithelial tissues are able to self-renew to maintain homeostasis and regenerate in response to injury remains a persistent question. The transcriptional effectors YAP and TAZ are increasingly being recognized as central mediators of epithelial stem cell biology, and a wealth of recent studies have been directed at understanding the control and activity of these factors. Recent work by Hu et al. has added to this knowledge, as they identify an Integrin-FAK-CDC42-PP1A signaling cascade that directs nuclear YAP/TAZ activity in stem cell populations of the mouse incisor, and define convergence on mTORC1 signaling as an important mediator of the proliferation of these cells. Here, we review recent studies on YAP/TAZ function and regulation in epithelial tissue-specific stem cells, merging the Hu et al. study together with our current knowledge of YAP/TAZ.
上皮组织如何能够自我更新以维持内稳态并在受伤时再生仍然是一个悬而未决的问题。转录效应因子 YAP 和 TAZ 越来越被认为是上皮干细胞生物学的核心介质，最近的大量研究都致力于理解这些因子的控制和活性。Hu 等人的最新研究为此提供了更多的知识，他们确定了一个整合素-FAK-CDC42-PP1A 信号级联，该信号级联在小鼠门牙的干细胞群体中指导核 YAP/TAZ 活性，并确定了 mTORC1 信号的收敛作为这些细胞增殖的重要介质。在这里，我们综述了最近关于上皮组织特异性干细胞中 YAP/TAZ 功能和调节的研究，将 Hu 等人的研究与我们目前对 YAP/TAZ 的了解结合起来。
