Departamento de Psicología, Universidad Loyola Andalucia, Sevilla, Spain.
Prevention and Health Promotion Research Network (redIAPP), ISCIII, Málaga, Spain.
BMJ Open. 2018 Nov 28;8(11):e022012. doi: 10.1136/bmjopen-2018-022012.
Although evidence exists for the efficacy of psychosocial interventions in preventing depression, little is known about its prevention through online interventions. The objective of this study is to conduct a systematic review and meta-analysis of randomised controlled trials assessing the effectiveness of online interventions in preventing depression in heterogeneous populations.
We will conduct a systematic review and meta-analysis of randomised controlled trials that will be identified through searches of PubMed, PsycINFO, WOS, Scopus, OpenGrey, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Australia New Zealand Clinical Trials Register . We will also search the reference lists provided in relevant studies and reviews. Experts in the field will be contacted to obtain more references. Two independent reviewers will assess the eligibility criteria of all articles, extract data and determine their risk of bias (Cochrane Collaboration Tool). Baseline depression will be required to have been discarded through standardised interviews or validated self-reports with standard cut-off points. The outcomes will be the incidence of new cases of depression and/or the reduction of depressive symptoms as measured by validated instruments. Pooled standardised mean differences will be calculated using random-effect models. Heterogeneity and publication bias will be estimated. Predefined sensitivity and subgroup analyses will be performed. If heterogeneity is relevant, random-effect meta-regression will be performed.
The results will be disseminated through peer-reviewed publication and will be presented at a professional conference. Ethical assessment is not required as we will search and assess existing sources of literature.
CRD42014014804; Results.
虽然有证据表明心理社会干预在预防抑郁症方面是有效的，但对于通过在线干预来预防抑郁症知之甚少。本研究的目的是对评估在线干预预防异质人群抑郁症的有效性的随机对照试验进行系统评价和荟萃分析。
我们将通过对 PubMed、PsycINFO、WOS、Scopus、OpenGrey、Cochrane 中央对照试验注册中心、ClinicalTrials.gov 和澳大利亚新西兰临床试验注册中心的搜索，对随机对照试验进行系统评价和荟萃分析。我们还将搜索相关研究和综述中提供的参考文献列表，并联系该领域的专家以获取更多参考文献。两名独立的审查员将评估所有文章的入选标准，提取数据并确定其偏倚风险（Cochrane 协作工具）。需要通过标准化访谈或使用标准截断值的验证性自我报告丢弃基线抑郁。结果将是新的抑郁症病例发生率和/或使用验证性工具衡量的抑郁症状减轻。使用随机效应模型计算汇总标准化均数差异。将估计异质性和发表偏倚。将进行预设的敏感性和亚组分析。如果存在异质性，将进行随机效应荟萃回归。
研究结果将通过同行评审出版物进行传播，并将在专业会议上展示。由于我们将搜索和评估现有文献来源，因此不需要进行伦理评估。
CRD42014014804；结果。
