Department of Rheumatology and immunology, Xiangya Hospital, Central South University, Changsha, China.
The Institute of Rheumatology and Immunology, Central South University, Changsha, China.
Front Immunol. 2018 Nov 15;9:2663. doi: 10.3389/fimmu.2018.02663. eCollection 2018.
Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an "alarmin" role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cells. Recent articles have described IL-33 as an emerging pro-fibrotic cytokine in the immune system as well as a novel potential target for systemic sclerosis. Here, we review the available information and focus on the pleiotropic expression and pathogenesis of IL-33 in systemic sclerosis, as well as the feasibility of using IL-33 in clinical applications.
白细胞介素-33 (IL-33)，白细胞介素-1 超家族的一员，作为一种传统的细胞因子和核因子发挥作用。它被认为具有“警报素”的作用。IL-33 通过与 ST2 受体和白细胞介素-1 受体辅助蛋白相互作用来介导生物学效应，特别是在先天免疫细胞和辅助性 T 细胞 2 中。最近的文章将 IL-33 描述为免疫系统中新兴的促纤维化细胞因子，也是系统性硬化症的一个新的潜在治疗靶点。在这里，我们回顾了现有的信息，并重点介绍了 IL-33 在系统性硬化症中的多效性表达和发病机制，以及 IL-33 在临床应用中的可行性。
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