Li Liya, Zuo Xiaoxia, Luo Hui, Li Yisha, You Yunhui, Duan Liping, Zhang Weiru, Zhao Hongjun, Li Tong, Ning Wangbin, Xie Yanli, Liu Sijia, Xie Xiaoyun, Jiang Ying, Wu Shiyao, Zhu Honglin, Zhou Ya'ou
Department of Rheumatology and Immunology, Xiangya Hospital, Central South University; Institute of Rheumatology and Immunology, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Aug 28;42(8):927-933. doi: 10.11817/j.issn.1672-7347.2017.08.009.
To analyze the trend relevant factors leading to death and their patterns over a 10-year period in inpatients with connective tissue diseases (CTDs). Methods: All clinical data about death in inpatients with CTDs were retrospectively reviewed between 2005 and 2014 at the Department of Rheumatology and Immunology in Xiangya Hospital of Central South University. Results: In the 10-year time period, the overall hospital mortality was 15.68‰. The disease itself accounted for 44.71% of the total causes of death, infection accounted for 42.94%, and comorbidities accounted for 12.35%. The constituent ratio of deaths and the average hospital mortality caused by the disease itself declined gradually year by year, and the constituent ratio of deaths caused by infection and comorbidities increased gradually year by year (P<0.05). In 2013-2014, infection was the leading cause of death, which accounted for 51.06%. The survival time for CTDs inpatients with interstitial lung disease (ILD) was shorter than that of CTDs inpatients without ILD, and even the risk of death was 1.722 times of the latter. The proportion of deaths caused by the disease itself was the highest in systemic sclerosis and systemic lupus erythematosus, that by infection was the highest in idiopathic inflammatory myopathy (IIM), and that by comorbidities was the highest in rheumatoid arthritis. Conclusion: The proportion of deaths and the hospital mortality in CTDs inpatients caused by the disease itself show a declining trend, while the proportion of deaths caused by infection and comorbidities increase. CTDs patients with ILD have shorter survival time and an increase in risk of death.
分析结缔组织病（CTD）住院患者10年间导致死亡的相关因素及其模式。方法：回顾性分析2005年至2014年中南大学湘雅医院风湿免疫科CTD住院患者的所有死亡临床资料。结果：10年间，总体医院死亡率为15.68‰。疾病本身占总死亡原因的44.71%，感染占42.94%，合并症占12.35%。疾病本身导致的死亡构成比及平均医院死亡率逐年逐渐下降，感染和合并症导致的死亡构成比逐年逐渐上升（P<0.05）。2013 - 2014年，感染是主要死亡原因，占51.06%。合并间质性肺病（ILD）的CTD住院患者的生存时间短于未合并ILD的CTD住院患者，甚至死亡风险是后者的1.722倍。疾病本身导致的死亡比例在系统性硬化症和系统性红斑狼疮中最高，感染导致的死亡比例在特发性炎性肌病（IIM）中最高，合并症导致的死亡比例在类风湿关节炎中最高。结论：CTD住院患者中疾病本身导致的死亡比例及医院死亡率呈下降趋势，而感染和合并症导致的死亡比例上升。合并ILD的CTD患者生存时间较短且死亡风险增加。
