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基于铜基配合物的连续流动光催化阿佩尔反应。

Photocatalyic Appel reaction enabled by copper-based complexes in continuous flow.

作者信息

Minozzi Clémentine, Grenier-Petel Jean-Christophe, Parisien-Collette Shawn, Collins Shawn K

机构信息

Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7, Canada.

出版信息

Beilstein J Org Chem. 2018 Oct 30;14:2730-2736. doi: 10.3762/bjoc.14.251. eCollection 2018.

DOI:10.3762/bjoc.14.251
PMID:30498523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6244115/
Abstract

A copper-based photocatalyst, Cu(tmp)(BINAP)BF, was found to be active in a photoredox Appel-type conversion of alcohols to bromides. The catalyst was identified from a screening of 50 complexes and promoted the transformation of primary and secondary alcohols to their corresponding bromides and carboxylic acids to their anhydrides. The protocol was also amendable and optimized under continuous flow conditions.

摘要

一种铜基光催化剂Cu(tmp)(BINAP)BF，被发现可在光氧化还原阿佩尔型反应中将醇转化为溴化物。该催化剂是从50种配合物的筛选中鉴定出来的，能促进伯醇和仲醇转化为相应的溴化物，以及羧酸转化为酸酐。该反应方案在连续流动条件下也是可修正和优化的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/234994a47c97/Beilstein_J_Org_Chem-14-2730-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/59b173ce394b/Beilstein_J_Org_Chem-14-2730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/86403d2e7e88/Beilstein_J_Org_Chem-14-2730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/9a8b25538687/Beilstein_J_Org_Chem-14-2730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/c185e98487ca/Beilstein_J_Org_Chem-14-2730-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/234994a47c97/Beilstein_J_Org_Chem-14-2730-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/59b173ce394b/Beilstein_J_Org_Chem-14-2730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/86403d2e7e88/Beilstein_J_Org_Chem-14-2730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/9a8b25538687/Beilstein_J_Org_Chem-14-2730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/c185e98487ca/Beilstein_J_Org_Chem-14-2730-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d2/6244115/234994a47c97/Beilstein_J_Org_Chem-14-2730-g006.jpg

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The photophysics of photoredox catalysis: a roadmap for catalyst design.
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