Raut Chandrajit P
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Visc Med. 2018 Oct;34(5):342-346. doi: 10.1159/000493474. Epub 2018 Oct 28.
One of the holy grails of cancer surgery for surgical oncologists is to perform a macroscopically complete resection of the affected organ or site with negative microscopic margins. The surgical oncologist must also be mindful of what constitutes appropriately-sized negative margins. However, what is necessary, based on the best available evidence, can vary considerably for different malignancies arising within the same organ. This review compares two different gastric and rectal malignancies, one each of epithelial and of mesenchymal origin. Data supporting extent of margins will be reviewed, illustrating the importance of knowing the histologic diagnosis prior to surgery to provide proper oncologic care.
对于外科肿瘤学家而言，癌症手术的一大圣杯是对受影响器官或部位进行宏观上完整的切除，且显微镜下切缘阴性。外科肿瘤学家还必须留意什么构成了合适大小的阴性切缘。然而，基于现有最佳证据，对于同一器官内发生的不同恶性肿瘤，所需的切缘可能差异很大。本综述比较了两种不同的胃和直肠恶性肿瘤，一种起源于上皮组织，另一种起源于间叶组织。将回顾支持切缘范围的数据，说明术前了解组织学诊断以提供适当肿瘤治疗的重要性。
