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瓜氨酸对盲肠结扎穿刺诱导脓毒症大鼠心脏的保护作用。

Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture.

机构信息

Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

出版信息

Biomed Res Int. 2018 Oct 18;2018:2574501. doi: 10.1155/2018/2574501. eCollection 2018.

DOI:10.1155/2018/2574501
PMID:30498752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6220746/
Abstract

PURPOSE

To investigate the protective effect of citrulline (Cit) on the hearts of rats with sepsis.

METHODS

Wistar rats were divided into the normal, sham-operated, CLP, Cit, and CLP+Cit groups. Routine blood tests were performed, and the blood biochemical indexes were measured. Pathological changes in the cardiac tissues were observed. The levels of NO and iNOS in blood and SOD activity and MDA levels in the heart were measured.

RESULTS

Less inflammatory cell infiltration of the myocardial fibers and significantly decreased white blood cell count, absolute neutrophil count, neutrophil percentage, CK, HBDH, and NO (all <0.05) were detected in the CLP+Cit group compared with the CLP group. In addition, SOD activity and MDA levels in heart tissues were, respectively, higher and lower in the CLP+Cit group than in the CLP group (both <0.05).

CONCLUSIONS

Cit reduces pathological damage in the heart and enhances the heart's antioxidant capacity, thereby protecting cardiomyocytes.

摘要

目的

研究瓜氨酸（Cit）对脓毒症大鼠心脏的保护作用。

方法

将 Wistar 大鼠分为正常组、假手术组、CLP 组、Cit 组和 CLP+Cit 组。进行常规血液检查，并测量血液生化指标。观察心脏组织的病理变化。测量血液中 NO 和 iNOS 的水平以及心脏中 SOD 活性和 MDA 水平。

结果

与 CLP 组相比，CLP+Cit 组心肌纤维的炎性细胞浸润较少，白细胞计数、绝对中性粒细胞计数、中性粒细胞百分比、CK、HBDH 和 NO 均显著降低（均<0.05）。此外，CLP+Cit 组心脏组织中的 SOD 活性和 MDA 水平分别高于和低于 CLP 组（均<0.05）。

结论

Cit 减轻了心脏的病理损伤，增强了心脏的抗氧化能力，从而保护了心肌细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/d03d233bee2b/BMRI2018-2574501.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/1fed335fe849/BMRI2018-2574501.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/076935b96491/BMRI2018-2574501.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/e234f86931e0/BMRI2018-2574501.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/d705a868e7d6/BMRI2018-2574501.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/d03d233bee2b/BMRI2018-2574501.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/1fed335fe849/BMRI2018-2574501.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/076935b96491/BMRI2018-2574501.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/e234f86931e0/BMRI2018-2574501.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/d705a868e7d6/BMRI2018-2574501.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7137/6220746/d03d233bee2b/BMRI2018-2574501.005.jpg

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