Internal Medicine Unit, Cannizzaro Hospital, Department of Clinical and Experimental Medicine, University of Catania, Via Messina, 829, 95100, Catania, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Rev Endocr Metab Disord. 2018 Dec;19(4):397-403. doi: 10.1007/s11154-018-9475-y.
The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic disorders, namely autoimmune thyroiditis, type 2 diabetes mellitus, and erectile/sexual dysfunctions. In this review, we summarize current knowledge on the endocrine/metabolic diseases associated with chronic HCV infection, focusing on the main concepts emerged in the recent literature in this field. The application of this knowledge in everyday clinical practice may be relevant, in order to reinforce a holistic vision of the patient with chronic HCV infection, stimulating in turn a multi-disciplinary approach, thus increasing the probability of early diagnosis, more effective treatments, and a better prognostic outcome.
“HCV 综合征”一词涵盖了几种器官和系统的病理生理状态，这些状态在其病理生理学中经常认识到自身免疫或肿瘤演变，以及慢性 HCV 感染作为触发因素。HCV 患者的临床特征具有异质性，可能包括内分泌或代谢紊乱，即自身免疫性甲状腺炎、2 型糖尿病和勃起/性功能障碍。在这篇综述中，我们总结了与慢性 HCV 感染相关的内分泌/代谢疾病的最新知识，重点介绍了该领域近期文献中出现的主要概念。将这些知识应用于日常临床实践可能具有相关性，以便加强对慢性 HCV 感染患者的整体认识，进而激发多学科方法，从而提高早期诊断、更有效治疗和更好预后的可能性。
