自身免疫性甲状腺疾病中的抗磷脂抗体。
Antiphospholipid antibodies in autoimmune thyroid diseases.
机构信息
Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia.
High School of Sciences and Techniques of Health, Tunis El Manar University, Tunis, Tunisia.
出版信息
J Clin Lab Anal. 2022 Dec;36(12):e24788. doi: 10.1002/jcla.24788. Epub 2022 Nov 25.
BACKGROUND
Antiphospholipid (aPL) antibodies have been reported in several autoimmune diseases. The aim of this study was to evaluate the frequency of aPL (anti-cardiolipin antibodies (aCL) and anti-β2 glycoprotein I antibodies (aβ2GPI)) in patients with autoimmune thyroid diseases (AITD).
METHODS
One hundred and ninety-five patients with AITD (139 Hashimoto's thyroiditis (HT) patients and 56 Graves' disease (GD) patients) and 90 healthy blood donors (HBD) were studied. IgG, IgA and IgM aCL and aβ2GPI were determined by ELISA.
RESULTS
One hundred fifty-four AITD patients were women and 41 were men. Fifty-six healthy subjects were women and 34 were men. The median age of patients and the control group was 45 and 38.5 years, respectively. The frequency of aPL was significantly higher in patients with AITD and in patients with HT than in HBD (33.3% vs 11.1%, p < 10 and 38.1% vs 11.1%, p < 10 ). The frequency of aPL in GD was significantly lower than in HT (21.4% vs 38.1%, p = 0.025). In patients with HT, aβ2GPI (34.5%) was significantly more frequent than aCL (13.6%) (p < 10 ). The frequency of aβ2GPI was significantly higher in patients with HT than in healthy population (34.5% vs 11.1%, p < 10 ). In HT patients, IgA isotype of aβ2GPI was significantly more common than in HBD and in GD patients (27.3% vs 7.8%, p < 10 and 27.3% vs 12.5%, p = 0.02, respectively).
CONCLUSION
aβ2GPI and not aCL were frequent in AITD. IgA was the predominant isotype of aβ2GPI. aβ2GPI-IgA was more frequent in HT than in GD.
背景
抗磷脂 (aPL) 抗体已在几种自身免疫性疾病中被报道。本研究旨在评估自身免疫性甲状腺疾病 (AITD) 患者中 aPL（抗心磷脂抗体 (aCL) 和抗-β2 糖蛋白 I 抗体 (aβ2GPI)）的频率。
方法
研究了 195 例 AITD 患者（139 例桥本甲状腺炎 (HT) 患者和 56 例格雷夫斯病 (GD) 患者）和 90 名健康献血者 (HBD)。通过 ELISA 测定 IgG、IgA 和 IgM aCL 和 aβ2GPI。
结果
154 例 AITD 患者为女性，41 例为男性。56 名健康受试者为女性，34 名男性。患者和对照组的中位年龄分别为 45 岁和 38.5 岁。AITD 患者和 HT 患者的 aPL 频率明显高于 HBD（33.3%比 11.1%，p<0.001 和 38.1%比 11.1%，p<0.001）。GD 患者的 aPL 频率明显低于 HT（21.4%比 38.1%，p=0.025）。在 HT 患者中，aβ2GPI（34.5%）明显比 aCL（13.6%）更常见（p<0.001）。HT 患者的 aβ2GPI 频率明显高于健康人群（34.5%比 11.1%，p<0.001）。在 HT 患者中，aβ2GPI 的 IgA 同种型明显比 HBD 和 GD 患者更常见（27.3%比 7.8%，p<0.001 和 27.3%比 12.5%，p=0.02，分别）。
结论
aβ2GPI 而不是 aCL 在 AITD 中频繁发生。IgA 是 aβ2GPI 的主要同种型。HT 中 aβ2GPI-IgA 比 GD 更常见。
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