Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada.
School of Human Kinetics, Laurentian University, Sudbury, Canada.
Br J Pharmacol. 2020 Feb;177(4):757-768. doi: 10.1111/bph.14556. Epub 2018 Dec 28.
Hydrogen sulfide (H S) is the most recently recognized gasotransmitter, influencing a wide range of physiological processes. As a critical regulator of metabolism, H S has been suggested to be involved in the pathology of many diseases, particularly obesity, diabetes and cardiovascular disorders. Its involvement in liver health has been brought to light more recently, particularly through knockout animal models, which show severe hepatic lipid accumulation upon ablation of H S metabolic pathways. A complex relationship between H S and lipid metabolism in the liver is emerging, which has significant implications for liver disease establishment and/or progression, regardless of the disease-causing agent. In this review, we discuss the critical importance of H S in hepatic lipid metabolism. We then describe the animal models so far related with H S and lipid-associated liver disease, as well as H S-based treatments available. Finally, we highlight important considerations for future studies and identify areas in which much still remains to be determined. LINKED ARTICLES: This article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc.
硫化氢（H2S）是最近被认可的气体信号分子，影响着广泛的生理过程。作为代谢的关键调节剂，H2S 被认为与许多疾病的病理学有关，特别是肥胖、糖尿病和心血管疾病。最近，人们对 H2S 在肝脏健康中的作用有了更深入的了解，特别是通过敲除动物模型，这些模型显示在 H2S 代谢途径被阻断后肝脏脂质积累严重。H2S 和肝脏脂质代谢之间出现了复杂的关系，这对肝脏疾病的发生和/或进展具有重要意义，无论致病因素如何。在这篇综述中，我们讨论了 H2S 在肝脏脂质代谢中的关键重要性。然后，我们描述了迄今为止与 H2S 和与脂质相关的肝脏疾病相关的动物模型，以及基于 H2S 的可用治疗方法。最后，我们强调了未来研究的重要考虑因素，并确定了仍有许多需要确定的领域。
本文是生物学与医学中硫化氢专题的一部分。要查看该部分中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc.
