Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.
NORMENT Centre of Excellence, University of Oslo, Oslo, Norway.
Curr Top Med Chem. 2018;18(21):1908-1924. doi: 10.2174/1568026619666181130103559.
Magnetic Resonance Spectroscopy (MRS) has become a valuable tool for investigating the biochemical bases of both normal processes in the healthy brain and elucidating the pathophysiology of neuropsychiatric disorders. As a rapidly advancing field, new developments in pulse sequence design have seen new possibilities arise in terms of what can be done with in vivo spectroscopy. While the applications of MRS are numerous, this review has been confined to the use of single voxel spectroscopy in the assessment of five key metabolites and their roles in schizophrenia: N-acetylaspartate (NAA), glutamate (Glu) and glutamine (Gln), γ-aminobutyric acid (GABA) and glutathione (GSH). This article will briefly cover the roles they play in schizophrenia, review current methods being used in their assessment and highlight new approaches that may potentially overcome some of the limitations current methods pose.
磁共振波谱（MRS）已成为研究健康大脑中正常过程的生化基础以及阐明神经精神疾病病理生理学的重要工具。作为一个快速发展的领域，脉冲序列设计的新进展为体内波谱学的应用带来了新的可能。尽管 MRS 的应用很多，但本综述仅限于单体素波谱在评估五个关键代谢物及其在精神分裂症中的作用：N-乙酰天冬氨酸（NAA）、谷氨酸（Glu）和谷氨酰胺（Gln）、γ-氨基丁酸（GABA）和谷胱甘肽（GSH）。本文将简要介绍它们在精神分裂症中的作用，回顾当前用于评估它们的方法，并强调可能克服当前方法存在的一些局限性的新方法。
