Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.
Biomark Med. 2018 Nov;12(11):1231-1239. doi: 10.2217/bmm-2018-0089. Epub 2018 Nov 30.
To explore the relationship between circulating bone-specific alkaline phosphatase (BALP) levels and abdominal aortic calcification (AAC) in patients receiving maintenance hemodialysis (MHD).
A total of 156 MHD patients were enrolled. Serum BALP levels were measured using ELISA, and AAC was assessed via lateral abdominal radiography.
BALP was positively correlated with AAC score (r = 0.389; p < 0.01). Multivariate logistic regression analysis showed that high-sensitivity C-reactive protein, dialysis vintage and BALP were independent risk factors for AAC in MHD patients. Receiver-operating characteristic analysis indicated that the area under the curve of BALP for the prediction of AAC was 0.737 (95% CI: 0.619-0.855; p < 0.01). When the detection cut-off level was 17.55 μg/l, its sensitivity was 81.7% and specificity was 74.5%.
Serum BALP is closely correlated with vascular calcification in MHD patients.
探讨维持性血液透析（MHD）患者循环骨特异性碱性磷酸酶（BALP）水平与腹主动脉钙化（AAC）的关系。
纳入 156 例 MHD 患者。采用 ELISA 法检测血清 BALP 水平，采用侧腹部放射摄影评估 AAC。
BALP 与 AAC 评分呈正相关（r=0.389，p<0.01）。多因素 logistic 回归分析显示，高敏 C 反应蛋白、透析龄和 BALP 是 MHD 患者 AAC 的独立危险因素。受试者工作特征分析表明，BALP 预测 AAC 的曲线下面积为 0.737（95%CI：0.619-0.855，p<0.01）。当检测截断值为 17.55μg/l 时，其灵敏度为 81.7%，特异性为 74.5%。
血清 BALP 与 MHD 患者的血管钙化密切相关。
