维持性血液透析患者循环骨特异性碱性磷酸酶与腹主动脉钙化。
Circulating bone-specific alkaline phosphatase and abdominal aortic calcification in maintenance hemodialysis patients.
机构信息
Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.
出版信息
Biomark Med. 2018 Nov;12(11):1231-1239. doi: 10.2217/bmm-2018-0089. Epub 2018 Nov 30.
AIM
To explore the relationship between circulating bone-specific alkaline phosphatase (BALP) levels and abdominal aortic calcification (AAC) in patients receiving maintenance hemodialysis (MHD).
METHODS
A total of 156 MHD patients were enrolled. Serum BALP levels were measured using ELISA, and AAC was assessed via lateral abdominal radiography.
RESULTS
BALP was positively correlated with AAC score (r = 0.389; p < 0.01). Multivariate logistic regression analysis showed that high-sensitivity C-reactive protein, dialysis vintage and BALP were independent risk factors for AAC in MHD patients. Receiver-operating characteristic analysis indicated that the area under the curve of BALP for the prediction of AAC was 0.737 (95% CI: 0.619-0.855; p < 0.01). When the detection cut-off level was 17.55 μg/l, its sensitivity was 81.7% and specificity was 74.5%.
CONCLUSION
Serum BALP is closely correlated with vascular calcification in MHD patients.
目的
探讨维持性血液透析（MHD）患者循环骨特异性碱性磷酸酶（BALP）水平与腹主动脉钙化（AAC）的关系。
方法
纳入 156 例 MHD 患者。采用 ELISA 法检测血清 BALP 水平，采用侧腹部放射摄影评估 AAC。
结果
BALP 与 AAC 评分呈正相关（r=0.389，p<0.01）。多因素 logistic 回归分析显示，高敏 C 反应蛋白、透析龄和 BALP 是 MHD 患者 AAC 的独立危险因素。受试者工作特征分析表明，BALP 预测 AAC 的曲线下面积为 0.737（95%CI：0.619-0.855，p<0.01）。当检测截断值为 17.55μg/l 时，其灵敏度为 81.7%，特异性为 74.5%。
结论
血清 BALP 与 MHD 患者的血管钙化密切相关。
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