[Association between sarcopenia and abdominal aortic calcification in maintenance hemodialysis patients].

To investigate the relationship between sarcopenia and abdominal aortic calcification (AAC) in maintenance hemodialysis (MHD) patients. A cross-sectional study was conducted. MHD patients who underwent regular dialysis between January 2021 and January 2022 at hemodialysis center in Jiangdu People's Hospital Affiliated to Yangzhou University were enrolled. The incidence of sarcopenia in these patients was examined by measuring handgrip strength, gait speed and appendicular skeletal muscle mass index (ASMI) using bioelectrical impedance analysis. AAC score was measured by a lateral lumbar spinal radiograph. The general information of the patients was collected and the blood biochemical indexes were detected. These patients were divided into non-calcification group (=104) and calcification group (=127) according to the score of AAC. Multivariate logistic regression was used to analyze the related factors of AAC. A total of 231 MHD patients (134 males and 97 females) were enrolled in the study, with the mean age of (57.1±11.4) years. Among 231 hemodialysis patients, the incidence of sarcopenia and AAC were 46.3% (107 cases) and 55.0% (127 cases), respectively. The age [(60.2±11.1) vs (53.4±12.2) years, <0.001] and dialysis vintage [86 (46, 135) vs 57 (27, 109) months, =0.005] in calcification group were longer than these in the non-calcification group. The level of 25(OH)D [17.7 (13.5, 24.3) vs 20.5 (15.1, 28.1) μg/L, =0.008] and gait speed [(0.88±0.23) vs (1.01±0.20) m/s, =0.024], handgrip strength [(17.9±9.1) vs (20.7±9.9) kg, =0.013], ASMI [(6.65±2.24) vs (7.83±2.46) kg/m, <0.001] were lower. While, AAC score [12 (9, 19) vs 0 (0, 3), <0.001] and the incidence of sarcopenia [58.3% (74/127) vs 31.7% (33/104), <0.001] were higher in the calcification group than these in the non-calcification group. Multivariate logistic regression analysis indicated that sarcopenia (=1.928, 95%: 1.302-2.855, =0.001), decrease of 25(OH)D level (=0.969, 95%: 0.940-1.000, =0.047), age (=1.043, 95%: 1.015-1.072, =0.002), and dialysis vintage (=1.009, 95%: 1.004-1.015, =0.001) were related factors of AAC. Sarcopenia is associated with AAC in MHD patients. In clinical practice, attention should be paid to sarcopenia in MHD patients.