Loehrer P J, Williams S D, Einhorn L H
Department of Medicine, Indiana University School of Medicine, Indianapolis.
J Natl Cancer Inst. 1988 Nov 2;80(17):1373-82. doi: 10.1093/jnci/80.17.1373.
Treatment for testicular cancer has dramatically improved during the last 15 years. Much of this success has come about because of improved staging and operative techniques but, most importantly, through the introduction of successful systemic chemotherapy. Nonetheless, relevant issues still remain to be addressed in regard to the optimal therapy for patients with germ cell neoplasms. Included in these issues is delineating the most effective but minimally morbid treatment for patients with early-stage and low-volume metastatic disease while continuing to create innovative treatment approaches for poor-risk patients with metastatic disease. The unique association of primary mediastinal germ cell neoplasms with the development of non-germ cell cancers and Klinefelter's syndrome may provide some early clues for the determination of factors controlling differentiation. These observations issue a challenge to both clinical and preclinical researchers involved in the study of this neoplasm.
在过去15年中，睾丸癌的治疗取得了显著进展。这种成功很大程度上归功于分期和手术技术的改进，但最重要的是，成功的全身化疗的引入。尽管如此，关于生殖细胞肿瘤患者的最佳治疗仍有相关问题有待解决。这些问题包括为早期和低体积转移性疾病患者确定最有效但并发症最少的治疗方法，同时继续为转移性疾病的高危患者创造创新的治疗方法。原发性纵隔生殖细胞肿瘤与非生殖细胞癌和克兰费尔特综合征的独特关联可能为确定控制分化的因素提供一些早期线索。这些观察结果对参与该肿瘤研究的临床和临床前研究人员都提出了挑战。
