Broder S
J Cancer Res Clin Oncol. 1991;117(4):290-4. doi: 10.1007/BF01630710.
The new decade has given birth to a large number of new concepts in our approach to cancer. The progress in molecular technology that occurred in the 1980's is being transferred in the 1990's to the bedside. The practical clinical application of basic science innovations is aimed at prevention and curative treatment of cancer in all of its forms, and is becoming a central theme of cancer therapeutics. The progress to date reflects a climate that fosters a unity of basic and clinical investigations, for example, where an understanding of tumor genetics or molecular immunoregulation can translate into an innovative clinical approach such as gene transfer therapy. The challenges that we face in this new decade arise in part from progress in certain areas, such as the discovery of natural products that have important antitumor activity but a limited source, or the increasing incidence in AIDS-related lymphomas that has come about from antiretroviral therapy-induced prolongation of survival for AIDS patients. There are critical challenges from a lack of progress in other areas, as well. The challenge of developing curative therapies is surpassed by the need to prevent those cancers before they arise. The challenge of prevention, as exemplified by the link between lung cancer and smoking, is of paramount importance. The ultimate challenge placed before the global oncology community is to ensure that the fruits of modern technology are available to all who need them.
新的十年为我们治疗癌症的方法带来了大量新观念。20世纪80年代分子技术取得的进展在90年代正被应用于临床。基础科学创新的实际临床应用旨在预防和治疗各种形式的癌症，正成为癌症治疗学的核心主题。迄今为止的进展反映出一种促进基础研究与临床研究相结合的氛围，例如，对肿瘤遗传学或分子免疫调节的理解能够转化为像基因转移疗法这样的创新性临床方法。在这个新的十年里，我们面临的挑战部分源于某些领域的进展，比如发现了具有重要抗肿瘤活性但来源有限的天然产物，或者由于抗逆转录病毒疗法延长了艾滋病患者的生存期，导致与艾滋病相关的淋巴瘤发病率上升。在其他一些领域缺乏进展也带来了严峻挑战。开发治愈性疗法的挑战，比不上在癌症发生之前预防这些癌症的需求。以肺癌与吸烟之间的联系为例，预防的挑战至关重要。摆在全球肿瘤学界面前的最终挑战是确保现代技术的成果能为所有有需要的人所用。
