[间充质干细胞及其外泌体在血管生成中的分子机制研究进展——综述]
[Advances of Researchs on Molecular Mechanisms of Mesenchymal Stem Cells and Their Exosomes in Angiogenesis--Review].
作者信息
Chen Jun-Qiu, Huang Liang-Hu
机构信息
PLA Organ Transplantation Institute, Fuzhou General Hospital, Fuzhou 350025, Fujian Province, China.
Fujian Provincial Key Laboratory of Transplant Biology, Dongfang Hospital Affiliated to Xiamen University, Fuzhou 350025, Fujian Province, China E-mail:
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Dec;26(6):1858-1862. doi: 10.7534/j.issn.1009-2137.2018.06.047.
Mesenchymal stem cells (MSC) have the potential of multi-directional differentiation, and can recruit endothelial cells, promote their proliferation, migration and angiogenesis, improve blood perfusion and oxygen suppliment, and repair damaged tissue. Exosome secreted by MSC contain mother cell-specific proteins, lipids and nucleic acids, and acts as signaling molecule, playing an important role in cell communication, thereby altering target cell function. In this review, the biological characteristics of MSC and its exosome, the mechanism of promoting vascular regeneration in patients with ischemic diseases, and the mechanism of hypoxia-inducible factor-1α（HIF-1α） in the vascular ischemia of ischemic diseases are all summarized briefly.
间充质干细胞（MSC）具有多向分化潜能，能够募集内皮细胞，促进其增殖、迁移和血管生成，改善血液灌注和氧气供应，并修复受损组织。MSC分泌的外泌体包含母细胞特异性蛋白质、脂质和核酸，并作为信号分子，在细胞通讯中发挥重要作用，从而改变靶细胞功能。在本综述中，简要总结了MSC及其外泌体的生物学特性、促进缺血性疾病患者血管再生的机制以及缺氧诱导因子-1α（HIF-1α）在缺血性疾病血管缺血中的作用机制。
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