NF-κB 信号通路对多发性骨髓瘤发病机制及现行治疗策略的影响。
The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma.
机构信息
Babak Myeloma Group, Department of Pathological Physiology, Masaryk University, Brno, Czech Republic.
Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
出版信息
Blood Rev. 2019 Mar;34:56-66. doi: 10.1016/j.blre.2018.11.003. Epub 2018 Nov 23.
Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-κB pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-κB pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-κB pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-κB for myeloma cells, however, is used against them, as current treatment strategies often use NF-κB as their primary or secondary target.
多发性骨髓瘤（MM）是第二大常见的血液系统恶性肿瘤，其遗传异质性极高。然而，在这个多样化的群体中，有一个途径尤为突出。NF-κB 通路不仅在发病机制中起重要作用，而且在各种治疗策略中也很重要，是多发性骨髓瘤中最重要的途径之一。NF-κB 通路的几个主要组成部分及其调节剂的突变至少存在于 17%的原发性多发性骨髓瘤肿瘤和 42%的多发性骨髓瘤细胞系中。NF-κB 通路调节许多基因，这些基因影响多发性骨髓瘤的发展和发病机制。然而，NF-κB 对骨髓瘤细胞的重要性却被利用了，因为目前的治疗策略经常将 NF-κB 作为其主要或次要靶点。
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