Dos Santos Horta R, Eunice Lavalle G, Narducci Monteiro L, Alves Dos Reis F B T M, de Pádua Costa M, Giuliano A, Dantas Cassali G, Dobson J
Department of Veterinary Medicine and Surgery, Brazil.
Department of Veterinary Medicine and Surgery, Brazil.
J Comp Pathol. 2018 Nov;165:72-81. doi: 10.1016/j.jcpa.2018.10.001. Epub 2018 Nov 20.
Mast cell tumours (MCTs) are one of the most frequent neoplasms in dogs. Glucocorticoids (GCs) are widely used in the management of this disease, although no guidelines for their use have been established. The aim of this study was to evaluate the correlation of MCT prognostic factors with measurable response to GCs. This retrospective study included 60 dogs treated with prednisone or prednisolone prior to surgical biopsy of MCT. Incisional or excisional biopsy was performed 7-14 days after initiation of GC therapy. Histopathology, immunohistochemical labelling for Ki67 and KITr, and polymerase chain reaction for the c-KIT gene were performed. Partial response occurred in 63.3% of cases (38/60), while 36.7% (22/60) did not respond. A response to GCs was correlated with lower stage of the disease, low histological grade, lower pattern of KITr expression and Ki67 score. Response to GCs was positively correlated with well-established favourable prognostic factors.
肥大细胞瘤（MCTs）是犬类最常见的肿瘤之一。糖皮质激素（GCs）被广泛用于该疾病的治疗，尽管尚未制定其使用指南。本研究的目的是评估MCT预后因素与对GCs可测量反应之间的相关性。这项回顾性研究纳入了60只在MCT手术活检前接受泼尼松或泼尼松龙治疗的犬。在开始GC治疗7 - 14天后进行切开活检或切除活检。进行了组织病理学检查、Ki67和KITr的免疫组化标记以及c-KIT基因的聚合酶链反应。63.3%的病例（38/60）出现部分反应，而36.7%（22/60）无反应。对GCs的反应与疾病分期较低、组织学分级低、KITr表达模式较低以及Ki67评分相关。对GCs的反应与已确立的良好预后因素呈正相关。
