Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Transplant Rev (Orlando). 2019 Apr;33(2):99-106. doi: 10.1016/j.trre.2018.11.002. Epub 2018 Nov 22.
Combined liver-lung transplantation (CLLT) is a rare, life-saving procedure to treat concomitant lung and liver disease. There have been 93 combined lung and liver transplantations performed in the United States since 1994. Techniques include both lung first and liver first sequential transplants with selective extracorporeal circulation of either thoracic or abdominal portions, with either end-to-end or Roux-en-Y choledochojejunostomy for biliary reconstruction. This review evaluates the existing literature regarding combined lung and liver transplantation (CLLT), describing the candidates, operation, perioperative complications, associated management strategies, and recommendations for immunosuppressive therapy and follow up.
联合肝肺移植（CLLT）是一种罕见的、拯救生命的治疗方法，用于治疗同时存在的肺部和肝脏疾病。自 1994 年以来，美国已经进行了 93 例联合肺和肝移植手术。技术包括肺先肝后序贯移植，选择性体外循环胸段或腹段，胆管重建采用端端吻合或 Roux-en-Y 胆肠吻合。本文回顾了关于联合肺和肝移植（CLLT）的现有文献，描述了候选者、手术、围手术期并发症、相关管理策略以及免疫抑制治疗和随访建议。
