Hébert Laurent, Guitton Edouard, Madeline Anthony, Géraud Tristan, Zientara Stéphan, Laugier Claire, Hans Aymeric, Büscher Philippe, Cauchard Julien, Petry Sandrine
ANSES, Dozulé Laboratory for Equine Diseases, Bacteriology Unit, 14430, Goustranville, France; ANSES, Dozulé Laboratory for Equine Diseases, Equines Virology and Parasitology Unit, 14430, Goustranville, France.
INRA, PFIE, UE1277, 37380, Nouzilly, France.
Vet Parasitol. 2018 Dec 15;264:47-51. doi: 10.1016/j.vetpar.2018.11.005. Epub 2018 Nov 9.
The aim of this study was to evaluate the ability of melarsomine hydrochloride (Cymelarsan) to cure horses suffering from a nervous form of dourine, a sexually-transmitted disease caused by Trypanosoma equiperdum. The recently described experimental model for assessing drug efficacy against horse trypanosomosis allowed us to obtain eight horses (Welsh pony mares) infected by T. equiperdum with parasites in their cerebrospinal fluid. The Cymelarsan treatment evaluated consisted of the daily administration of 0.5 mg/kg of Cymelarsan over 7 days. Two control horses remained untreated, three horses received the treatment 36 days p.i. and three horses received the treatment 16 days p.i. Following treatment, we observed parasite clearance in blood, stabilization of rectal temperature and a relative improvement in the mean packed cell volume levels for all treated horses. However, live parasites were later observed again in the CSF of all treated horses. Our results indicate the inability of Cymelarsan to reach Trypanozoon located in the central nervous system of infected horses and thus discourage the use of Cymelarsan to treat animals suffering from a nervous form of dourine.
本研究的目的是评估盐酸美拉胂醇（拜耳205）治愈患有神经型马媾疫（一种由马媾疫锥虫引起的性传播疾病）马匹的能力。最近描述的评估抗马锥虫病药物疗效的实验模型使我们能够获得8匹感染马媾疫锥虫且脑脊液中有寄生虫的马（威尔士矮种马母马）。所评估的拜耳205治疗方案为连续7天每天按0.5mg/kg的剂量给药。2匹对照马未接受治疗，3匹马在感染后36天接受治疗，3匹马在感染后16天接受治疗。治疗后，我们观察到所有接受治疗的马匹血液中的寄生虫清除、直肠温度稳定以及平均红细胞压积水平相对改善。然而，后来在所有接受治疗的马匹的脑脊液中再次观察到活的寄生虫。我们的结果表明，拜耳205无法到达位于感染马中枢神经系统中的锥虫，因此不建议使用拜耳205治疗患有神经型马媾疫的动物。
