血清纤维蛋白原样蛋白 2 浓度与创伤性脑损伤患者 30 天死亡率的关系。
The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury.
机构信息
Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 322000, Zhejiang Province, China.
Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 322000, Zhejiang Province, China.
出版信息
Clin Chim Acta. 2019 Feb;489:53-57. doi: 10.1016/j.cca.2018.11.033. Epub 2018 Nov 29.
BACKGROUND
Fibrinogen-like protein 2 (FGL2) is an inflammatory procoagulant protein. We discerned the impact of serum FGL2 on trauma severity and 30-day mortality in patients with traumatic brain injury (TBI).
METHODS
A total of 114 severe TBI patients were subjected to assessment of trauma severity using the Glasgow coma scale (GCS). Measurement of the serum concentrations of FGL2 was done. 114 matched control subjects for their age and sex were included for comparison of serum concentration of FGL2.
RESULTS
The concentration of FGL2 was dramatically increased in the patients as compared with the control subjects. FGL2 concentration was inversely correlated with GCS score among the patients. The non-survivors within 30 days exhibited substantially higher FGL2 concentrations than the alive. FGL2 concentrations discriminated the patients at risk of 30-day death with significantly high area under receiver operating characteristic curve. Serum FGL2 emerged as an independent predictor for mortality and overall survival at 30 days after head trauma.
CONCLUSIONS
Serum FGL2 is a promising biomarker for assessing the severity and prognosis in severe TBI.
背景
纤维蛋白原样蛋白 2（FGL2）是一种炎症性促凝蛋白。我们探讨了血清 FGL2 对创伤性脑损伤（TBI）患者创伤严重程度和 30 天死亡率的影响。
方法
对 114 例严重 TBI 患者进行格拉斯哥昏迷评分（GCS）评估创伤严重程度。检测血清 FGL2 浓度。选择 114 例年龄和性别匹配的对照者，比较血清 FGL2 浓度。
结果
与对照组相比，患者的 FGL2 浓度明显升高。患者中 FGL2 浓度与 GCS 评分呈负相关。30 天内死亡的非幸存者的 FGL2 浓度明显高于存活者。FGL2 浓度可通过显著高的受试者工作特征曲线下面积区分 30 天死亡风险患者。血清 FGL2 是颅脑外伤后 30 天死亡和总生存的独立预测因子。
结论
血清 FGL2 是评估严重 TBI 严重程度和预后的有前途的生物标志物。
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