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Treatment approach for young, fit, newly diagnosed multiple myeloma patients.

作者信息

Usmani Saad Z, Seifter Eric

机构信息

Plasma Cell Disorders Section, Department of Hematologic Oncology & Blood Disorders, Levine Cancer Institute/Atrium Health, Charlotte, NC; and.

Johns Hopkins University School of Medicine, Baltimore, MD.

出版信息

Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):97-102. doi: 10.1182/asheducation-2018.1.97.

DOI:10.1182/asheducation-2018.1.97
PMID:30504297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6246032/
Abstract
摘要

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A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.通过基因组分析鉴定的一组新诊断骨髓瘤的高危、双重打击群体。
Leukemia. 2019 Jan;33(1):159-170. doi: 10.1038/s41375-018-0196-8. Epub 2018 Jul 2.
2
Impact of duration of induction therapy on survival in newly diagnosed multiple myeloma patients undergoing upfront autologous stem cell transplantation.新诊断多发性骨髓瘤患者行 upfront 自体造血干细胞移植时诱导治疗时间对生存的影响。
Br J Haematol. 2018 Jul;182(1):71-77. doi: 10.1111/bjh.15244. Epub 2018 Apr 29.
3
Improvement in Overall Survival With Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma.卡非佐米、来那度胺和地塞米松治疗复发或难治性多发性骨髓瘤患者的总生存期改善。
J Clin Oncol. 2018 Mar 10;36(8):728-734. doi: 10.1200/JCO.2017.76.5032. Epub 2018 Jan 17.
4
Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma.达雷妥尤单抗联合硼替佐米、美法仑和泼尼松治疗未经治疗的多发性骨髓瘤。
N Engl J Med. 2018 Feb 8;378(6):518-528. doi: 10.1056/NEJMoa1714678. Epub 2017 Dec 12.
5
High somatic mutation and neoantigen burden are correlated with decreased progression-free survival in multiple myeloma.高体细胞突变和新抗原负担与多发性骨髓瘤患者无进展生存期缩短相关。
Blood Cancer J. 2017 Sep 22;7(9):e612. doi: 10.1038/bcj.2017.94.
6
Lenalidomide Maintenance After Autologous Stem-Cell Transplantation in Newly Diagnosed Multiple Myeloma: A Meta-Analysis.来那度胺维持治疗在新诊断的多发性骨髓瘤自体干细胞移植后的应用：一项荟萃分析。
J Clin Oncol. 2017 Oct 10;35(29):3279-3289. doi: 10.1200/JCO.2017.72.6679. Epub 2017 Jul 25.
7
Prospective Evaluation of Magnetic Resonance Imaging and [F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.IFM/DFCI 2009试验中纳入的有症状多发性骨髓瘤患者在诊断时及维持治疗前进行磁共振成像和[F]氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描的前瞻性评估：IMAJEM研究结果
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N Engl J Med. 2017 Apr 6;376(14):1311-1320. doi: 10.1056/NEJMoa1611750.
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Role of F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group.F-FDG PET/CT 在多发性骨髓瘤和其他浆细胞疾病的诊断和管理中的作用：国际骨髓瘤工作组的共识声明。
Lancet Oncol. 2017 Apr;18(4):e206-e217. doi: 10.1016/S1470-2045(17)30189-4.
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Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial.硼替佐米联合来那度胺和地塞米松与单纯来那度胺和地塞米松治疗新诊断的无立即自体干细胞移植意向的骨髓瘤患者（SWOG S0777）：一项随机、开放标签的3期试验
Lancet. 2017 Feb 4;389(10068):519-527. doi: 10.1016/S0140-6736(16)31594-X. Epub 2016 Dec 23.