Murata Taku, Kutsuna Tomohiko, Kurohara Kazuto, Shimizu Kasumi, Tomeoku Akira, Arai Naoya
Department of Oral and Maxillofacial Surgery, Department of Clinical Sciences, Medical Life Science, Mie University, Graduate School of Medicine, Mie, Japan
Department of Oral and Maxillofacial Surgery, Department of Clinical Sciences, Medical Life Science, Mie University, Graduate School of Medicine, Mie, Japan.
Anticancer Res. 2018 Dec;38(12):6715-6720. doi: 10.21873/anticanres.13040.
BACKGROUND/AIM: Due to its abilities of substance adsorption and intracellular transportation, hydroxyapatite is a potential carrier in drug delivery systems (DDS). This in vitro study investigated whether newly-developed, highly-dispersive calcined hydroxyapatite nanoparticles with an average grain diameter of 20 nm (nano-SHAP) were suitable as a DDS for the drugs zoledronic acid (ZA), cisplatin, and carboplatin.
The effects of drug-bearing nano-SHAP on cell proliferation were assessed using three human oral squamous cell carcinoma cell lines (HSC-4, KOSC, and SAS) and one human breast cancer cell line (MCF-7).
Nano-SHAP alone did not affect proliferation of any cell line until a concentration of 1 μg/ml was reached. Although the effective concentration of ZA in ZA-bearing nano-SHAP differed, it inhibited cell proliferation better than ZA alone. Cisplatin and carboplatin-bearing nano-SHAP had the same effect as these drugs alone.
The nano-SHAP system is of potential use as a drug delivery system.
背景/目的：由于具有物质吸附和细胞内转运能力，羟基磷灰石是药物递送系统（DDS）中的一种潜在载体。本体外研究调查了新开发的平均粒径为20nm的高度分散煅烧羟基磷灰石纳米颗粒（纳米-SHAP）是否适合作为唑来膦酸（ZA）、顺铂和卡铂的药物递送系统。
使用三种人类口腔鳞状细胞癌细胞系（HSC-4、KOSC和SAS）和一种人类乳腺癌细胞系（MCF-7）评估载药纳米-SHAP对细胞增殖的影响。
在达到1μg/ml浓度之前，单独的纳米-SHAP对任何细胞系的增殖均无影响。尽管载ZA纳米-SHAP中ZA的有效浓度有所不同，但它比单独的ZA更能抑制细胞增殖。载顺铂和卡铂的纳米-SHAP与单独使用这些药物具有相同的效果。
纳米-SHAP系统作为药物递送系统具有潜在用途。
