Cui Shuxia, Liu Hanzhe, Cui Guanglin
Henan Stomatological Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
School of Stomatology, Wuhan University, Wuhan, China.
Front Pharmacol. 2023 May 24;14:1176422. doi: 10.3389/fphar.2023.1176422. eCollection 2023.
Oral squamous cell carcinoma (OSCC) is a common human malignancy with an estimated incidence of around 377,713 new cases worldwide in 2020. Despite the advance in clinical management, some of OSCC patients still miss the opportunity of completable resection of tumor, and have to accept medical therapies, e.g., chemotherapy, radiotherapy, or immunotherapy when the disease develops into the advanced stage. However, these therapies have been reported to be far from ideal due to the low efficiency of conventional delivery approaches. To obtain a better therapeutic effect, considerable attempts have been made toward to develop an effective drug delivery system (DDS). Nanoparticles (NPs) including inorganic NPs, polymer NPs, lipid NP, extracellular vesicles and cell membrane-based NPs have been evaluated as the better DDS candidates that can specifically accumulate in the tumor microenvironment along with a large amount of blood vessels. Emerging evidence suggested that NPs formulated with anticancer drugs including chemotherapeutic drugs, radiotherapy and immunotarget antibodies could remarkably improve the release and increase concentration of these drugs at the tumor site and show a better therapeutic efficacy, suggesting that NPs might serve as promising DDSs in the treatment of OSCC. Therefore, we have conducted this review to summarize recent progression and current status of diverse NPs as DDSs in this research field.
口腔鳞状细胞癌（OSCC）是一种常见的人类恶性肿瘤，据估计2020年全球新发病例约为377,713例。尽管临床管理有所进步，但一些OSCC患者仍错过肿瘤完全切除的机会，疾病发展到晚期时不得不接受化疗、放疗或免疫治疗等医学疗法。然而，据报道，由于传统给药方法效率低下，这些疗法远非理想。为了获得更好的治疗效果，人们已经做出了大量尝试来开发有效的药物递送系统（DDS）。包括无机纳米颗粒、聚合物纳米颗粒、脂质纳米颗粒、细胞外囊泡和基于细胞膜的纳米颗粒在内的纳米颗粒已被评估为更好的DDS候选物，它们可以在富含大量血管的肿瘤微环境中特异性积累。新出现的证据表明，用包括化疗药物、放疗和免疫靶向抗体在内的抗癌药物制备的纳米颗粒可以显著改善这些药物在肿瘤部位的释放并增加其浓度，并显示出更好的治疗效果，这表明纳米颗粒可能是治疗OSCC的有前景的DDS。因此，我们进行了本综述，以总结该研究领域中作为DDS的各种纳米颗粒的最新进展和现状。
