Mathew Rani, Najeem Bangalath, Sobhanakumary Kunjumani, Sunny Beena, Pinheiro Carol, Anukumar Balakrishnan
Department of Dermatology and Venereology, Government T D Medical College, Alappuzha, Kerala, India.
Taluk Head Quarters Hospital, Palakkad, Kerala, India.
Indian J Dermatol. 2018 Nov-Dec;63(6):475-478. doi: 10.4103/ijd.IJD_187_17.
Herpes genitalis is an ulcerating sexually transmitted infection, the clinical importance of which lies in its ability to produce painful and recurrent disease in addition to its potential role as a cofactor in acquisition and transmission of human immunodeficiency virus. In recent years, there are increasing reports of genital herpes due to herpes simplex virus (HSV)-1 from various parts of the world. Molecular diagnostic methods such as polymerase chain reaction (PCR) have got both diagnostic and prognostic significance in genital herpes.
The present study was designed to identify the viral serotype in herpes genitalis patients in our locality, using PCR.
The specimens from forty herpes genitalis patients were subjected to nested PCR and results were evaluated.
PCR was positive for HSV in 83% of cases, of which 58% were due to HSV-1. HSV-2 accounted for maximum number of recurrent herpes.
Higher sample size would have been more representative.
A rising trend of type 1 HSV was observed in herpes genitalis in south India probably due to increasing practice of orogenital sex.
生殖器疱疹是一种溃疡性性传播感染，其临床重要性在于它除了作为人类免疫缺陷病毒获取和传播的辅助因素的潜在作用外，还能够引发疼痛和复发性疾病。近年来，世界各地关于单纯疱疹病毒（HSV）-1引起的生殖器疱疹的报道日益增多。聚合酶链反应（PCR）等分子诊断方法在生殖器疱疹中具有诊断和预后意义。
本研究旨在使用PCR鉴定我们当地生殖器疱疹患者中的病毒血清型。
对40例生殖器疱疹患者的标本进行巢式PCR并评估结果。
83%的病例PCR检测HSV呈阳性，其中58%是由HSV-1引起的。HSV-2导致复发性疱疹的病例数最多。
样本量越大则越具代表性。
在印度南部，生殖器疱疹中观察到HSV-１型呈上升趋势，这可能是由于口交行为增多所致。
