Sapre Ajay A, Novitskaya Ekaterina, Vakharia Ved, Cota Alejandro, Wrasidlo Wolfgang, Hanrahan Stephen M, Derenzo Stephen, Makale Milan T, Graeve Olivia A
University of California, San Diego, Department of Bioengineering, 9500 Gilman Drive - MC 0412, La Jolla, CA 92093-0412, USA.
University of California, San Diego, Department of Mechanical and Aerospace Engineering, 9500 Gilman Drive - MC 0411, La Jolla, CA 92093-0411, USA.
Mater Lett. 2018 Oct 1;228:49-52. doi: 10.1016/j.matlet.2018.05.090. Epub 2018 May 20.
We describe a sol-gel synthetic method for the production of praseodymium-doped yttrium aluminum garnet (YAG) nanoparticles suitable for X-ray inducible photodynamic therapy (X-PDT). Our sol-gel based approach was optimized by varying temperature and time of calcination, resulting in nanoparticles that were smooth, spherical, and 50-200 nm in crystallite size. The powders were uniformly coated with a thin (10 nm) layer of silica to facilitate surface conjugation with functional moieties. Measurements of photon flux revealed that coated and uncoated powders emitted a similar photon emission spectrum in response to 50 keVp X-rays. We also determined that the presence of silica did not significantly reduce flux and the emission peak had a maximum at approximately 320 nm. Thus, these YAG:Pr powders are suitable candidates for future X-PDT studies.
我们描述了一种用于制备适用于X射线诱导光动力疗法（X-PDT）的掺镨钇铝石榴石（YAG）纳米颗粒的溶胶-凝胶合成方法。我们基于溶胶-凝胶的方法通过改变煅烧温度和时间进行了优化，得到了光滑、球形且微晶尺寸为50-200nm的纳米颗粒。这些粉末均匀地涂覆有一层薄（10nm）的二氧化硅层，以促进与功能部分的表面共轭。光子通量测量表明，涂覆和未涂覆的粉末在50keVp X射线照射下发射出相似的光子发射光谱。我们还确定二氧化硅的存在不会显著降低通量，并且发射峰在约320nm处达到最大值。因此，这些YAG:Pr粉末是未来X-PDT研究的合适候选材料。
