Institute for Intelligent Bio/Chem Manufacturing (iBCM), ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, 311200, Zhejiang, China.
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310007, China.
J Nanobiotechnology. 2024 Oct 25;22(1):655. doi: 10.1186/s12951-024-02931-5.
Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments to address this significant medical and societal challenge. In recent years, X-ray-induced photodynamic therapy (X-PDT) has emerged as a promising advancement, revolutionizing traditional photodynamic therapy (PDT) for deeply entrenched malignancies by harnessing penetrating X-rays as external stimuli. Recent developments in X-ray photodynamic therapy have shown a trend toward minimizing radiation doses to remarkably low levels after the proof-of-concept demonstration. Early detection and real-time monitoring are crucial aspects of effective cancer treatment. Sophisticated X-ray imaging techniques have been enhanced by the introduction of X-ray luminescence nano-agents, alongside contrast nanomaterials based on X-ray attenuation. X-ray luminescence-based in vivo imaging offers excellent detection sensitivity and superior image quality in deep tissues at a reasonable cost, due to unhindered penetration and unimpeded auto-fluorescence of X-rays. This review emphasizes the significance of X-ray responsive theranostics, exploring their mechanism of action, feasibility, biocompatibility, and promising prospects in imaging-guided therapy for deep-seated tumors. Additionally, it discusses promising applications of X-PDT in treating breast cancer, liver cancer, lung cancer, skin cancer, and colorectal cancer.
全球死亡率数据表明，癌症是全球第二大致死原因。因此，迫切需要创新有效的治疗方法来应对这一重大的医学和社会挑战。近年来，X 射线诱导光动力疗法（X-PDT）作为一种有前途的进展，通过利用穿透性 X 射线作为外部刺激，彻底改变了传统的光动力疗法（PDT），为根深蒂固的恶性肿瘤提供了新的治疗方法。在概念验证演示之后，X 射线光动力疗法的最新发展趋势是将辐射剂量显著降低到极低水平。早期检测和实时监测是有效癌症治疗的关键方面。引入 X 射线发光纳米剂和基于 X 射线衰减的对比纳米材料，增强了复杂的 X 射线成像技术。X 射线发光的体内成像具有优异的检测灵敏度和高质量的图像，成本合理，因为 X 射线的穿透性和自发荧光不受阻碍。这篇综述强调了 X 射线响应治疗学的重要性，探讨了其作用机制、可行性、生物相容性以及在深部肿瘤的成像引导治疗中的广阔前景。此外，还讨论了 X-PDT 在治疗乳腺癌、肝癌、肺癌、皮肤癌和结直肠癌方面的有前途的应用。
