Zarei Parvin, Rezvanfar Mohammad Reza, Ansarihadipour Hadi, Delavar Mostafa, Abdollahi Mahdi, Khosrowbeygi Ali
Department of Biochemistry and Genetics, Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Department of Internal Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
J Res Med Sci. 2018 Oct 26;23:91. doi: 10.4103/jrms.JRMS_970_17. eCollection 2018.
Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q (CoQ) is a nonenzymatic antioxidant that restores other antioxidants.
This randomized, double-blind placebo-controlled trial study has been designed to evaluate the effects of CoQ supplementation on serum values of amylase, adenosine deaminase, catalase (CAT), total antioxidant capacity (TAC) and the quantitative insulin sensitivity check index (QUICKI) in women with T2DM. Serum levels of CoQ were measured too. Sixty-eight women with T2DM were enrolled in this study and randomly divided into two groups. One group received 100 mg/day of CoQ supplement for 12 weeks ( = 34), and the other group was given placebo for the same time duration and dosage ( = 34).
After the intervention, serum CAT activity ( < 0.001), TAC ( = 0.006), CoQ ( = 0.001), and QUICKI ( = 0.005) increased and fasting blood sugar (FBS) ( = 0.05) decreased significantly in CoQ group.
This study showed that daily supplementation with 100 mg of CoQ could increase TAC and CAT activity as, CoQ and QUICKI and could reduce oxidative stress and FBS in women with T2DM.
活性氧水平升高是2型糖尿病（T2DM）发病机制中的一个关键因素。辅酶Q（CoQ）是一种能恢复其他抗氧化剂的非酶抗氧化剂。
本随机、双盲、安慰剂对照试验旨在评估补充CoQ对T2DM女性血清淀粉酶、腺苷脱氨酶、过氧化氢酶（CAT）、总抗氧化能力（TAC）和定量胰岛素敏感性检查指数（QUICKI）值的影响。同时也测量了血清CoQ水平。68名T2DM女性参与了本研究，并随机分为两组。一组接受100毫克/天的CoQ补充剂，为期12周（n = 34），另一组在相同时间和剂量下给予安慰剂（n = 34）。
干预后，CoQ组血清CAT活性（P < 0.001）、TAC（P = 0.006）、CoQ（P = 0.001）和QUICKI（P = 0.005）升高，空腹血糖（FBS）（P = 0.05）显著降低。
本研究表明，每日补充100毫克CoQ可提高TAC和CAT活性，升高CoQ和QUICKI，并可降低T2DM女性的氧化应激和FBS。
