补充辅酶Q10对成年人人体测量指标的影响：一项随机对照试验的系统评价和荟萃分析
Effects of Coenzyme Q10 Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
作者信息
Ghavami Abed, Mohammadi Hamed, Hadi Amir, Ziaei Rahele, Nattagh-Eshtivani Elyas, Sheykhrobat Mohammad Veysi, Askari Gholamreza
机构信息
Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2020 Nov 26;11:181. doi: 10.4103/ijpvm.IJPVM_179_19. eCollection 2020.
BACKGROUND
Obesity is related to increase in the incidence of morbidity and mortality. Previous studies have led to conflicting results regarding the effect of coenzyme Q10 (CoQ10) supplementation on anthropometric indices. This study aimed to evaluate the efficacy of CoQ10 supplementation on body weight, body mass index (BMI), and waist circumference (WC) through a systematic review and meta-analysis of randomized controlled trials (RCTs).
METHODS
PubMed, Scopus, Web of Science, and Cochrane Library as well as the reference lists of the identified relevant RCTs were searched up to March 2019, and weighted mean differences (WMDs) were pooled by using the random-effects model.
RESULTS
Twenty RCTs (976 participants) were eligible to be included in the systematic review. The meta-analysis revealed that CoQ10 supplementation had no effect on body weight (WMD = -0.04 kg; 95% confidence interval [CI]: -1.96, 1.6; = 0.0%), BMI (WMD = -0.06 kg/m; 95% CI: -0.54, 0.42; = 0.0%), and WC (WMD = 0.79 cm; 95% CI: -2.83, 0.04; = 0.0%).
CONCLUSIONS
CoQ10 supplementation might not improve anthropometric indices. Future well-designed trials are still needed to confirm these results.
背景
肥胖与发病率和死亡率的增加有关。先前的研究对于补充辅酶Q10（CoQ10）对人体测量指标的影响得出了相互矛盾的结果。本研究旨在通过对随机对照试验（RCT）进行系统评价和荟萃分析，评估补充CoQ10对体重、体重指数（BMI）和腰围（WC）的疗效。
方法
检索了截至2019年3月的PubMed、Scopus、科学网和考克兰图书馆以及已识别的相关RCT的参考文献列表，并使用随机效应模型汇总加权平均差（WMD）。
结果
20项RCT（976名参与者）符合纳入系统评价的条件。荟萃分析显示，补充CoQ10对体重（WMD = -0.04 kg；95%置信区间[CI]：-1.96，1.6；P = 0.0%）、BMI（WMD = -0.06 kg/m²；95% CI：-0.54，0.42；P = 0.0%）和WC（WMD = 0.79 cm；95% CI：-2.83，0.04；P = 0.0%）均无影响。
结论
补充CoQ10可能无法改善人体测量指标。仍需要未来设计良好的试验来证实这些结果。
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