Meindl Alison G, Lourenço Bianca N, Coleman Amanda E, Creevy Kate E
Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, Athens, Georgia.
J Vet Intern Med. 2019 Jan;33(1):192-199. doi: 10.1111/jvim.15377. Epub 2018 Dec 2.
Proteinuria is a marker of chronic kidney disease in dogs and a risk factor for increased morbidity and death. Predictive models using the results of readily available screening tests could foster early recognition.
To determine whether urine specific gravity (USG) and semiquantitative category of dipstick protein can be used to predict urinary protein-to-creatinine ratio (UP : C) and to examine the effect of urine culture results on UP : C in dogs.
Three hundred ninety-four dogs (482 visits) presented to a university Community Practice Clinic or Veterinary Teaching Hospital between January 2011 and November 2015.
Retrospective study. Medical records were searched to identify dogs for which urinalysis, UP : C measurement, and urine culture testing were performed during a single hospital visit. Urine specific gravity, UP : C, dipstick protein concentration, and findings of urine sediment analysis and urine culture were recorded. Regression or Spearman correlation analysis was used to test for relationships between UP : C and USG within dipstick categories and between UP : C and bacterial colony-forming units per milliliter, respectively. Cohen's kappa test was used to evaluate agreement between urine culture and UP : C testing.
There were significant (P < .05) weak negative correlations (R range, 0.14-0.37) between UP : C and USG for all nonnegative urine protein dipstick categories. The presence of a positive urine culture did not agree with the presence of abnormal UP : C (κ = -0.06).
Within dipstick protein categories, UP : C cannot be accurately predicted from USG. Repeating UP : C measurement after resolution of urinary tract infection is advisable.
蛋白尿是犬慢性肾病的一个指标，也是发病率和死亡率增加的一个风险因素。使用易于获得的筛查测试结果的预测模型有助于早期识别。
确定尿比重（USG）和试条法蛋白质半定量类别是否可用于预测尿蛋白与肌酐比值（UP : C），并检查尿培养结果对犬UP : C的影响。
2011年1月至2015年11月期间到一所大学社区实践诊所或兽医教学医院就诊的394只犬（482次就诊）。
回顾性研究。检索病历以确定在单次医院就诊期间进行了尿液分析、UP : C测量和尿培养检测的犬。记录尿比重、UP : C、试条法蛋白质浓度以及尿沉渣分析和尿培养的结果。分别使用回归或Spearman相关分析来检验试条法类别内UP : C与USG之间以及UP : C与每毫升细菌菌落形成单位之间的关系。使用Cohen卡方检验来评估尿培养与UP : C检测之间的一致性。
对于所有非负尿蛋白试条法类别，UP : C与USG之间存在显著（P < .05）的弱负相关（R范围为0.14 - 0.37）。尿培养阳性与UP : C异常不一致（κ = -0.06）。
在试条法蛋白质类别内，无法根据USG准确预测UP : C。建议在尿路感染治愈后重复测量UP : C。
