Róg Beata, Okólska Magdalena, Dziedzic-Oleksy Hanna, Sałapa Kinga, Rubiś Paweł, Kopeć Grzegorz, Podolec Piotr, Tomkiewicz-Pająk Lidia
Department of Cardiovascular Diseases, Cardiological Outpatient Clinic, John Paul II Hospital, Krakow, Poland.
Department of Bioinformatics and Telemedicine, Jagiellonian University, Krakow, Poland.
Acta Cardiol. 2019 Dec;74(6):517-524. doi: 10.1080/00015385.2018.1530084. Epub 2018 Dec 3.
The coarctation of aorta is commonly related to bicuspid aortic valve. The aim of the study was to assess arterial stiffness in adults after aortic coarctation repair and to evaluate an impact of bicuspid aortic valve concomitance on arterial stiffness results. Fifty-eight patients after coarctation of aorta repair, 36 male, median age of 27.46 ± 10.57, were compared to 30 with bicuspid aortic valve and to 30 healthy, sex, age and BMI matched volunteers. Physical examination, laboratory analysis and non-invasive assessment of arterial stiffness were performed. CoA patients and BAV patients have higher central arterial stiffness parameters in comparison to healthy controls: AP (7.86 ± 6.56 vs 7.68 ± 5.96 vs 1.41 ± 3.82 mmHg, < 0.001, = 0.011, respectively) and AIx (18.81 ± 14.94 vs 18.06 ± 13.38 vs 4.41 ± 10.82%, < 0.001, = 0.006, respectively). There were no differences of PWV between CoA patients, BAV patients and healthy controls (6.07 ± 1.20 vs 5.95 ± 1.20 vs 5.67 ± 0.73 m/s, = 0.099, = 0.278, respectively). In CoA group, there was correlation of PWV with age ( = 0.55 < 0.001), BMI ( = 0.29, = 0.025), fibrinogen ( = 0.31, = 0.039), glucose ( = 0.58, < 0.001), ascending aorta diameter ( = 0.29, = 0.026) and age at operation ( = 0.27, = 0.041). Among group of BAV, there was a correlation of PWV with age ( = 0.58, < 0.001), central AP with total cholesterol ( = 0.38, = 0.036) and fibrinogen ( = 0.41, = 0.024). The increased arterial stiffness occurs in both groups: patients after aortic coarctation repair and patients with bicuspid aortic valve. Concomitance of coarctation of the aorta and bicuspid aortic valve has no influence on arterial stiffness augmentation.
主动脉缩窄通常与二叶式主动脉瓣有关。本研究的目的是评估主动脉缩窄修复术后成人的动脉僵硬度，并评估二叶式主动脉瓣合并存在对动脉僵硬度结果的影响。将58例主动脉缩窄修复术后患者（36例男性，中位年龄27.46±10.57岁）与30例二叶式主动脉瓣患者及30例年龄、性别和BMI匹配的健康志愿者进行比较。进行了体格检查、实验室分析和动脉僵硬度的无创评估。与健康对照组相比，主动脉缩窄（CoA）患者和二叶式主动脉瓣（BAV）患者的中心动脉僵硬度参数更高： augmentation. 分别为7.86±6.56 vs 7.68±5.96 vs 1.41±3.82 mmHg，P<0.001，P = 0.011）和增强指数（AIx）（分别为18.81±14.94 vs 18.06±13.38 vs 4.41±10.82%，P<0.001，P = 0.006）。CoA患者、BAV患者和健康对照组之间的脉搏波速度（PWV）没有差异（分别为6.07±1.20 vs 5.95±1.20 vs 5.67±0.73 m/s，P = 0.099，P = 0.278）。在CoA组中，PWV与年龄（P = 0.55，P<0.001）、BMI（P = 0.29，P = 0.025）、纤维蛋白原（P = 0.31，P = 0.039）、血糖（P = 0.58，P<0.001）、升主动脉直径（P = 0.29，P = 0.026）和手术年龄（P = 0.27，P = 0.041）相关。在BAV组中，PWV与年龄（P = 0.58，P<0.001）、中心动脉压与总胆固醇（P = 0.38，P = 0.036）和纤维蛋白原（P = 0.41，P = 0.024）相关。两组均出现动脉僵硬度增加：主动脉缩窄修复术后患者和二叶式主动脉瓣患者。主动脉缩窄和二叶式主动脉瓣的合并存在对动脉僵硬度增加没有影响。
