Kuban K C, Skouteli H, Cherer A, Brown E, Leviton A, Pagano M, Allred E, Sullivan K F
Department of Neurology, Harvard Medical School, Boston.
Pediatrics. 1988 Oct;82(4):548-53.
Fifty-one sequential intubated babies with birth weights of less than 1,751 were evaluated by serial Doppler ultrasound during the first three days of life. These babies were part of a phenobarbital prophylaxis trial cohort study. Subependymal-intraventricular hemorrhage developed in 17 of the babies. Infants with subependymal-intraventricular hemorrhage, whether or not they received pancuronium or phenobarbital, had coefficients of variation comparable to those of babies without hemorrhage. Coefficient of variation values of the right were comparable to values obtained from the left anterior cerebral artery complex and did not appear to be consistently altered by the presence of subependymal-intraventricular hemorrhage. Coefficient of variation values appeared to be consistently greatest on day 1 and lowest on day 2. In addition, the values overall increased as the number of waves used to determine the coefficient of variation enlarged from five to 20. This phenomena, however, was not seen among pancuronium recipients and suggests that movement artifact may be a determinant of coefficient of variation values. We conclude that, when the best 20 waves are chosen to evaluate the coefficient of variation, no association exists between coefficient of variation values and development of subependymal-intraventricular hemorrhage or administration of phenobarbital.
对51例出生体重小于1751克且相继接受插管的婴儿在出生后三天内进行了连续多普勒超声评估。这些婴儿是苯巴比妥预防试验队列研究的一部分。17例婴儿发生了室管膜下-脑室内出血。发生室管膜下-脑室内出血的婴儿，无论是否接受泮库溴铵或苯巴比妥治疗，其变异系数与未出血的婴儿相当。右侧的变异系数值与从左大脑前动脉复合体获得的值相当，并且似乎不会因室管膜下-脑室内出血的存在而持续改变。变异系数值似乎在第1天始终最大，在第2天最低。此外，随着用于确定变异系数的波数从5个增加到20个，总体值会增加。然而，在接受泮库溴铵治疗的婴儿中未观察到这种现象，这表明运动伪影可能是变异系数值的一个决定因素。我们得出结论，当选择最佳的20个波来评估变异系数时，变异系数值与室管膜下-脑室内出血的发生或苯巴比妥的给药之间不存在关联。
