Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, Taiwan; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung City, Taiwan.
Department of Applied Mathematics, Tunghai University, Taichung, Taiwan.
Int J Drug Policy. 2019 Feb;64:1-4. doi: 10.1016/j.drugpo.2018.11.010. Epub 2018 Dec 1.
To investigate boosting effects on treatment stabilization in the mandatory treatment modality for patients of amphetamine-type stimulant use disorder.
This is a retrospective follow-up study over a period from January 2013 to December 2018. We analyzed 425 patients of amphetamine-type stimulant use disorder under mandating treatments. Treatment stabilization for a given patient was defined once 4 negative urinalysis had been observed. We developed a dynamic monitoring model of boosting effects informed by the available data, specifically the number of negative urine samples required to reach stabilization, the sum of urinalyses done at the time when the given number of negative urine samples had been observed and who the patient was. To represent the simulated population, a Monte Carlo method was used to generate p-values from 1000 experiments conducted on a computer.
In the observed samples, the probability of 4 negative results in urinalysis from 4 outpatient visits was 75.5%. In comparison, the probability for achieving 4th negative results in urinalysis over 4 visits from negative binominal distribution was 57.3%, and from the computer simulation, 49.8%. The observed samples had significantly higher probability of achieving 4 negative results in urinalysis over 4 outpatient visits (p < 0.001).
The mandatory treatment modality boosted treatment stabilization for patients of amphetamine-type stimulant use disorder. The major benefit of using the monitoring model is the ability to monitor boosting effects of stabilization. Results supported the effectiveness of this mandatory treatment modality and can be implemented in deferred-prosecution based treatment modality.
研究安非他命类兴奋剂使用障碍患者强制治疗模式下的促进稳定作用。
这是一项回顾性随访研究，时间为 2013 年 1 月至 2018 年 12 月。我们分析了 425 名接受安非他命类兴奋剂强制治疗的患者。对于给定的患者，一旦观察到 4 次阴性尿检，即定义为治疗稳定。我们根据可用数据开发了一种促进稳定作用的动态监测模型，具体涉及达到稳定所需的阴性尿检次数、观察到给定数量的阴性尿检样本时进行的尿检次数总和以及患者是谁。为了代表模拟人群，我们使用蒙特卡罗方法在计算机上进行了 1000 次实验，生成了 p 值。
在观察样本中，4 次门诊阴性尿检结果的概率为 75.5%。相比之下，4 次阴性尿检结果的概率分别为阴性二项式分布的 57.3%和计算机模拟的 49.8%。观察样本中，在 4 次门诊随访中达到 4 次阴性尿检结果的概率显著更高（p<0.001）。
强制治疗模式促进了安非他命类兴奋剂使用障碍患者的治疗稳定。监测模型的主要优势在于能够监测稳定的促进作用。结果支持这种强制性治疗模式的有效性，并可应用于基于延期起诉的治疗模式。
