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在男性低促性腺激素性性腺功能减退症患者中，经皮下脉冲式GnRH治疗后静脉注射GnRH引发的超敏反应。

Hypersensitivity reaction with intravenous GnRH after pulsatile subcutaneous GnRH treatment in male hypogonadotrophic hypogonadism.

作者信息

Popović V, Milosević Z, Djukanović R, Micić D, Nesović M, Manojlović D, Djordjević P, Mićić J

机构信息

Clinic for Endocrinology and Immunology, University Clinic, School of Medicine, Belgrade, Yugoslavia.

出版信息

Postgrad Med J. 1988 Mar;64(749):245-6. doi: 10.1136/pgmj.64.749.245.

DOI:10.1136/pgmj.64.749.245
PMID:3050944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2428843/
Abstract

Chronic pulsatile subcutaneous administration of low doses of gonadotrophin releasing hormone (GnRH) is an effective therapy for men with hypogonadotrophic hypogonadism. Hypersensitivity reactions to GnRH are rare. We wish to report hypersensitivity reactions with intravenous GnRH after low dose subcutaneous pulsatile GnRH treatment in two men with hypogonadotrophic hypogonadism due to suprasellar disease.

摘要

长期皮下脉冲式给予低剂量促性腺激素释放激素（GnRH）是治疗低促性腺激素性性腺功能减退男性的有效方法。对GnRH的过敏反应罕见。我们希望报告两例因鞍上疾病导致低促性腺激素性性腺功能减退的男性患者，在接受低剂量皮下脉冲式GnRH治疗后出现静脉注射GnRH过敏反应的情况。

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Hypersensitivity reaction to intranasal gonadotropin-releasing hormone.对鼻内促性腺激素释放激素的超敏反应。
Eur J Pediatr. 1995 Mar;154(3):248. doi: 10.1007/BF01954288.

本文引用的文献

1
Induction of male puberty by long-term pulsatile subcutaneous LH-RH therapy.
Ups J Med Sci. 1984;89(1):73-80. doi: 10.3109/03009738409178466.
2
Events surrounding the initiation of puberty with long term subcutaneous pulsatile gonadotropin-releasing hormone in a female patient with Kallman's syndrome.患有卡尔曼综合征的女性患者使用长期皮下脉冲式促性腺激素释放激素引发青春期的相关事件。
J Clin Endocrinol Metab. 1985 Sep;61(3):575-9. doi: 10.1210/jcem-61-3-575.
3
Pulsatile gonadotropin-releasing hormone therapy in male patients with Kallmann's syndrome or constitutional delay of puberty.脉冲式促性腺激素释放激素疗法治疗患有卡尔曼综合征或体质性青春期延迟的男性患者。
Fertil Steril. 1985 Apr;43(4):599-608. doi: 10.1016/s0015-0282(16)48504-3.

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