Happ J, Ditscheid W, Krause U
Fertil Steril. 1985 Apr;43(4):599-608. doi: 10.1016/s0015-0282(16)48504-3.
The response to low-dose pulsatile gonadotropin-releasing hormone (GnRH) therapy was tested in three hypogonadotropic hypogonadal male patients and a boy with delayed puberty showing different luteinizing hormone responses (delta LH) to test doses of 25 micrograms GnRH intravenously before treatment. Four male patients, 16 to 20 years of age, three with Kallmann's syndrome and one with idiopathic delay of puberty, received 2 micrograms GnRH subcutaneously every 2 1/2 hours for 3 months by the use of the Zyklomat pump (Ferring GmbH, Kiel, FRG). In two patients with Kallmann's syndrome and decreased delta LH, serum testosterone did not increase during treatment, even after increasing the dosage and changing the route of administration (4 micrograms subcutaneously or 8 micrograms intravenously every 2 1/2 hours for 4 weeks with every dosage). The third patient with Kallmann's syndrome and the boy with delayed puberty, both with normal delta LH, presented normal serum testosterone after 3 months of subcutaneous low-dose treatment. The different responses to a GnRH test dose corresponding to the response to pulsatile GnRH therapy probably reflect different degrees of maturation of the pituitary gonadotrophs.
在三名低促性腺激素性性腺功能减退男性患者和一名青春期延迟男孩中测试了低剂量脉冲式促性腺激素释放激素（GnRH）疗法的反应，这几名患者在治疗前静脉注射25微克GnRH测试剂量时显示出不同的促黄体生成素反应（ΔLH）。四名年龄在16至20岁的男性患者，三名患有卡尔曼综合征，一名患有特发性青春期延迟，使用Zyklomat泵（德国基尔的Ferring GmbH公司）每2.5小时皮下注射2微克GnRH，持续3个月。在两名患有卡尔曼综合征且ΔLH降低的患者中，即使增加剂量并改变给药途径（每2.5小时皮下注射4微克或静脉注射8微克，持续4周，每种剂量），治疗期间血清睾酮也未增加。第三名患有卡尔曼综合征的患者和青春期延迟男孩，两者的ΔLH均正常，在皮下低剂量治疗3个月后血清睾酮呈现正常。对GnRH测试剂量的不同反应与对脉冲式GnRH疗法的反应相对应，这可能反映了垂体促性腺细胞不同程度的成熟。
