Pelleg A, Miyagawa A, Michelson E L, Dreifus L S
Lankenau Medical Research Center, Philadelphia, PA 19151.
Prog Clin Biol Res. 1988;275:225-37.
Adenosine and ATP exert pronounced electrophysiologic actions on the mammalian heart including a negative chronotropic action on cardiac pacemakers and a negative dromotropic action on atrioventricular conduction. These actions are modulated by complex interactions of the two compounds with the autonomic nervous system. Since both adenosine and ATP are released from myocardial cells under physiologic and pathophysiologic conditions, they could play an important modulating role in cardiac electrophysiology. Indeed, studies during the last decade have yielded strong evidence for the role of adenosine in the genesis of specific arrhythmias associated with myocardial ischemia. Further studies are required to fully elucidate the mechanisms of actions of adenosine and ATP in vivo. These will undoubtedly enhance the understanding of the potential arrhythmogenic, as well as the antiarrhythmic actions of endogenous and exogenous adenosine and ATP.
腺苷和三磷酸腺苷（ATP）对哺乳动物心脏具有显著的电生理作用，包括对心脏起搏器的负性变时作用以及对房室传导的负性变传导作用。这两种化合物与自主神经系统的复杂相互作用调节着这些作用。由于腺苷和ATP在生理和病理生理条件下均从心肌细胞释放，它们可能在心脏电生理中发挥重要的调节作用。事实上，过去十年的研究已为腺苷在与心肌缺血相关的特定心律失常发生中所起的作用提供了有力证据。需要进一步研究以充分阐明腺苷和ATP在体内的作用机制。这无疑将增进对内源性和外源性腺苷及ATP潜在的致心律失常以及抗心律失常作用的理解。
