Belhassen B, Pelleg A
J Am Coll Cardiol. 1984 Aug;4(2):414-24. doi: 10.1016/s0735-1097(84)80233-8.
Adenosine triphosphate (ATP) and adenosine have strong negative chronotropic and dromotropic effects on the mammalian heart. The sensitivity of the sinus node and the atrioventricular node to ATP and adenosine manifests pronounced variability among species. For more than three decades, ATP has been used routinely in Europe in the acute therapy of paroxysmal supraventricular tachycardia. Preliminary clinical trials with adenosine in the United States suggest that this compound may have a similar therapeutic value. The exact mechanisms of action of ATP and adenosine on the mammalian heart are still not fully known. However, the vast clinical experience indicates that ATP, and probably also adenosine, can be safely and repetitively used in the acute therapy of paroxysmal supraventricular tachycardia.
三磷酸腺苷（ATP）和腺苷对哺乳动物心脏具有强烈的负性变时性和变传导性作用。窦房结和房室结对ATP和腺苷的敏感性在不同物种间表现出明显差异。三十多年来，ATP在欧洲一直被常规用于阵发性室上性心动过速的急性治疗。美国腺苷的初步临床试验表明，该化合物可能具有类似的治疗价值。ATP和腺苷对哺乳动物心脏的确切作用机制仍不完全清楚。然而，大量临床经验表明，ATP以及可能还有腺苷，可安全且重复地用于阵发性室上性心动过速的急性治疗。
