成功救治一只患有淋巴瘤的犬多柔比星过量及外渗病例
Successful management of doxorubicin overdose and extravasation in a dog with lymphoma.
作者信息
Kicenuik Kristin S, Northrup Nicole C, Clarke Dawn M, Bazzle Lisa J
机构信息
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens Georgia 30602, USA.
出版信息
Can Vet J. 2018 Oct;59(10):1079-1084.
Abstract
A dog was hospitalized after accidental overdose and extravasation of doxorubicin. With supportive care and dexrazoxane, systemic toxicity resolved by Day 9 and extravasation injury by Day 36. This case demonstrates that, with treatment, dogs can survive doxorubicin overdose and extravasation. The report also highlights the importance of checking the dose of chemotherapeutic agents and preventing extravasation.
摘要
一只狗因阿霉素意外过量和外渗而住院。经过支持治疗和给予右丙亚胺，全身毒性在第9天消退，外渗损伤在第36天痊愈。该病例表明，经过治疗，狗可以从阿霉素过量和外渗中存活下来。该报告还强调了检查化疗药物剂量和预防外渗的重要性。
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本文引用的文献
1
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Vet Comp Oncol. 2016 Dec;14(4):417-446. doi: 10.1111/vco.283.
2
2016 Updated American Society of Clinical Oncology/Oncology Nursing Society Chemotherapy Administration Safety Standards, Including Standards for Pediatric Oncology.2016年更新的美国临床肿瘤学会/肿瘤护理学会化疗给药安全标准，包括儿科肿瘤学标准。
Oncol Nurs Forum. 2017 Jan 6;44(1):31-43. doi: 10.1188/17.ONF.31-43.
3
2016 AAHA Oncology Guidelines for Dogs and Cats.2016年美国动物医院协会犬猫肿瘤学指南。
J Am Anim Hosp Assoc. 2016 Jul-Aug;52(4):181-204. doi: 10.5326/JAAHA-MS-6570. Epub 2016 Jun 3.
4
Medical error-the third leading cause of death in the US.医疗差错——美国第三大死因。
BMJ. 2016 May 3;353:i2139. doi: 10.1136/bmj.i2139.
5
Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update.美国临床肿瘤学会临床实践指南更新：白细胞生长因子的应用建议。
J Clin Oncol. 2015 Oct 1;33(28):3199-212. doi: 10.1200/JCO.2015.62.3488. Epub 2015 Jul 13.
6
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7
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9
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J Radiat Res. 2011;52(4):472-80. doi: 10.1269/jrr.10103.
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