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成功救治一只患有淋巴瘤的犬多柔比星过量及外渗病例

Successful management of doxorubicin overdose and extravasation in a dog with lymphoma.

作者信息

Kicenuik Kristin S, Northrup Nicole C, Clarke Dawn M, Bazzle Lisa J

机构信息

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens Georgia 30602, USA.

出版信息

Can Vet J. 2018 Oct;59(10):1079-1084.

PMID:30510312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6135299/
Abstract

A dog was hospitalized after accidental overdose and extravasation of doxorubicin. With supportive care and dexrazoxane, systemic toxicity resolved by Day 9 and extravasation injury by Day 36. This case demonstrates that, with treatment, dogs can survive doxorubicin overdose and extravasation. The report also highlights the importance of checking the dose of chemotherapeutic agents and preventing extravasation.

摘要

一只狗因阿霉素意外过量和外渗而住院。经过支持治疗和给予右丙亚胺,全身毒性在第9天消退,外渗损伤在第36天痊愈。该病例表明,经过治疗,狗可以从阿霉素过量和外渗中存活下来。该报告还强调了检查化疗药物剂量和预防外渗的重要性。

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Successful management of doxorubicin overdose and extravasation in a dog with lymphoma.成功救治一只患有淋巴瘤的犬多柔比星过量及外渗病例
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本文引用的文献

1
Veterinary cooperative oncology group - common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1.兽医肿瘤协作组——犬猫化疗或生物抗肿瘤治疗后不良事件通用术语标准(VCOG-CTCAE)v1.1版
Vet Comp Oncol. 2016 Dec;14(4):417-446. doi: 10.1111/vco.283.
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2016 Updated American Society of Clinical Oncology/Oncology Nursing Society Chemotherapy Administration Safety Standards, Including Standards for Pediatric Oncology.2016年更新的美国临床肿瘤学会/肿瘤护理学会化疗给药安全标准,包括儿科肿瘤学标准。
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Medical error-the third leading cause of death in the US.医疗差错——美国第三大死因。
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Efficacy of intravenous administration of combined acid suppressants in healthy dogs.联合酸抑制剂静脉注射对健康犬的疗效。
J Vet Intern Med. 2015 Mar-Apr;29(2):556-60. doi: 10.1111/jvim.12555. Epub 2015 Feb 25.
7
Dexrazoxane for the treatment of chemotherapy-related side effects.地塞米松预防化疗所致副作用。
Cancer Manag Res. 2014 Sep 15;6:357-63. doi: 10.2147/CMAR.S47238. eCollection 2014.
8
Glutamine for chemotherapy induced diarrhea: a meta-analysis.谷氨酰胺用于化疗引起的腹泻:一项荟萃分析。
Asia Pac J Clin Nutr. 2012;21(3):380-5.
9
Dexrazoxane treatment of doxorubicin extravasation injury in four dogs.右丙亚胺对四只犬阿霉素外渗性损伤的治疗
J Am Vet Med Assoc. 2012 Feb 1;240(3):304-7. doi: 10.2460/javma.240.3.304.
10
RhG-CSF improves radiation-induced myelosuppression and survival in the canine exposed to fission neutron irradiation.rhG-CSF 可改善接受裂变中子照射犬的辐射诱导骨髓抑制和生存。
J Radiat Res. 2011;52(4):472-80. doi: 10.1269/jrr.10103.