Bostwick D G
Department of Pathology, University of Maryland School of Medicine, Mercy Medical Center, Baltimore 21202.
Semin Diagn Pathol. 1988 Aug;5(3):240-53.
Two putative premalignant lesions of the prostate have been identified. Prostatic intraepithelial neoplasia (PIN) is characterized by proliferation and anaplasia of cells lining ducts and acini. Atypical adenomatous hyperplasia (AAH) consists of a localized proliferation of small round glands without cytologic atypia. PIN and AAH may be confused with well-differentiated carcinoma as well as florid hyperplasia, basal cell hyperplasia, transitional metaplasia, seminal vesicular epithelium, and atypia due to inflammation, infarction, and radiation. These premalignant lesions appear to have a high predictive value for carcinoma, and their presence on prostatic biopsy warrants further search for concurrent invasive adenocarcinoma. The use of strict morphologic criteria and uniform nomenclature will ensure standardization in the diagnosis of premalignant lesions of the prostate.
已确定前列腺的两种假定癌前病变。前列腺上皮内瘤变（PIN）的特征是导管和腺泡内衬细胞的增殖和间变。非典型腺瘤样增生（AAH）由小圆形腺体的局限性增殖组成，无细胞学异型性。PIN和AAH可能与高分化癌以及 florid增生、基底细胞增生、移行化生、精囊上皮以及炎症、梗死和放疗引起的异型性相混淆。这些癌前病变似乎对癌具有较高的预测价值，前列腺活检中它们的存在值得进一步寻找同时存在的浸润性腺癌。使用严格的形态学标准和统一的命名将确保前列腺癌前病变诊断的标准化。
