[腺瘤样增生结节中的癌前病变和良性病变]
[Premalignant and benign lesions in nodules of adenomatous hyperplasia].
作者信息
Miján Ortiz J L, Fernández Rodríguez A, Fernández Ruiz P L, de la Fuente Serrano A, Nogales Fernández F, Zuluaga Gómez A
机构信息
Servicio de Urología, Hospital Universitario de Granada, España.
出版信息
Arch Esp Urol. 1996 Sep;49(7):684-7.
OBJECTIVES
Currently, two premalignant lesions have been recognized: prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (AAH). Due to the possible clinical implications of these lesions, we attempted to determine their incidence in specimens of benign prostatic hyperplasia (BPH), the most frequent pathology of the prostate.
METHODS
A pathological and immunohistochemical study using several markers was performed to detect premalignant lesions in 156 specimens obtained by adenomectomy and TUR from 1990 to 1992.
RESULTS
20 PIN and 8 AAH (20.6%) were found. There were other equivocal prostatic lesions, not only with respect to premalignant lesions but prostatic carcinoma as well.
CONCLUSIONS
Premalignant lesions within BPH nodules are frequent (20.6%). Furthermore, other lesions were also found that caused difficulty in making the differential diagnosis.
目的
目前，已识别出两种癌前病变：前列腺上皮内瘤变（PIN）和非典型腺瘤样增生（AAH）。鉴于这些病变可能具有的临床意义，我们试图确定它们在前列腺最常见的病理类型——良性前列腺增生（BPH）标本中的发生率。
方法
对1990年至1992年通过腺瘤切除术和经尿道前列腺切除术获取的156份标本进行了病理及免疫组化研究，使用多种标志物检测癌前病变。
结果
发现20例PIN和8例AAH（20.6%）。还存在其他不明确的前列腺病变，不仅在癌前病变方面，在前列腺癌方面也是如此。
结论
BPH结节内的癌前病变很常见（20.6%）。此外，还发现了其他在鉴别诊断上存在困难的病变。
Zotero 插件